Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김동하 | * |
dc.date.accessioned | 2022-03-29T16:31:14Z | - |
dc.date.available | 2022-03-29T16:31:14Z | - |
dc.date.issued | 2021 | * |
dc.identifier.issn | 1936-0851 | * |
dc.identifier.issn | 1936-086X | * |
dc.identifier.other | OAK-31055 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/261002 | - |
dc.description.abstract | Hybrid nanostructures are promising for ultrasound-triggered drug delivery and treatment, called sonotheranostics. Structures based on plasmonic nanoparticles for photothermal-induced microbubble inflation for ultrasound imaging exist. However, they have limited therapeutic applications because of short microbubble lifetimes and limited contrast. Photochemistry-based sonotheranostics is an attractive alternative, but building near-infrared (NIR)-responsive echogenic nanostructures for deep tissue applications is challenging because photolysis requires high-energy (UV-visible) photons. Here, we report a photochemistry-based echogenic nanoparticle for in situ NIR-controlled ultrasound imaging and ultrasound-mediated drug delivery. Our nanoparticle has an upconversion nanoparticle core and an organic shell carrying gas generator molecules and drugs. The core converts low-energy NIR photons into ultraviolet emission for photolysis of the gas generator. Carbon dioxide gases generated in the tumor-penetrated nanoparticle inflate into microbubbles for sonotheranostics. Using different NIR laser power allows dual-modal upconversion luminescence planar imaging and cross-sectional ultrasonography. Low-frequency (10 MHz) ultrasound stimulated microbubble collapse, releasing drugs deep inside the tumor through cavitation-induced transport. We believe that the photoechogenic inflatable hierarchical nanostructure approach introduced here can have broad applications for image-guided multimodal theranostics. | * |
dc.language | English | * |
dc.publisher | AMER CHEMICAL SOC | * |
dc.subject | ultrasound | * |
dc.subject | upconversion | * |
dc.subject | near-infrared | * |
dc.subject | microbubble | * |
dc.subject | nanohybrid | * |
dc.title | Photoechogenic Inflatable Nanohybrids for Upconversion-Mediated Sonotheranostics | * |
dc.type | Article | * |
dc.relation.issue | 11 | * |
dc.relation.volume | 15 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 18394 | * |
dc.relation.lastpage | 18402 | * |
dc.relation.journaltitle | ACS NANO | * |
dc.identifier.doi | 10.1021/acsnano.1c07898 | * |
dc.identifier.wosid | WOS:000747115200114 | * |
dc.author.google | Jeong, Keunsoo | * |
dc.author.google | Kim, Dojin | * |
dc.author.google | Kim, Hyun Jun | * |
dc.author.google | Lee, Yong-Deok | * |
dc.author.google | Yoo, Jounghyun | * |
dc.author.google | Jang, Dohyub | * |
dc.author.google | Lee, Seokyung | * |
dc.author.google | Park, Hyeonjong | * |
dc.author.google | Kim, Youngsun | * |
dc.author.google | Singh, Ajay | * |
dc.author.google | Ahn, Dong June | * |
dc.author.google | Kim, Dong Ha | * |
dc.author.google | Bang, Joona | * |
dc.author.google | Kim, Jungahn | * |
dc.author.google | Prasad, Paras N. | * |
dc.author.google | Kim, Sehoon | * |
dc.contributor.scopusid | 김동하(26039227400) | * |
dc.date.modifydate | 20240123104500 | * |