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Bitter taste receptors protect against skin aging by inhibiting cellular senescence and enhancing wound healing
- Title
- Bitter taste receptors protect against skin aging by inhibiting cellular senescence and enhancing wound healing
- Authors
- Chung M.G.; Kim Y.; Cha Y.K.; Park T.H.
- Ewha Authors
- 김유리
- SCOPUS Author ID
- 김유리
- Issue Date
- 2022
- Journal Title
- Nutrition Research and Practice
- ISSN
- 1976-1457
- Citation
- Nutrition Research and Practice vol. 16, no. 1, pp. 1 - 13
- Keywords
- Galactose; Keratinocytes; Skin aging; Taste; Wound healing
- Publisher
- Korean Nutrition Society
- Indexed
- SCIE; SCOPUS; KCI
- Document Type
- Article
- Abstract
- BACKGROUND/OBJECTIVES: Bitter taste receptors are taste signaling pathway mediators, and are also expressed and function in extra-gustatory organs. Skin aging affects the quality of life and may lead to medical issues. The purpose of this study was to better understand the anti-skin aging effects of bitter taste receptors in D-galactose (D-gal)-induced aged human keratinocytes, HaCaT cells. MATERIALS/METHODS: Expressions of bitter taste receptors in HaCaT cells and mouse skin tissues were examined by polymerase chain reaction assay. Bitter taste receptor was overexpressed in HaCaT cells, and D-gal was treated to induce aging. We examined the effects of bitter taste receptors on aging by using β-galactosidase assay, wound healing assay, and Western blot assay. RESULTS: TAS2R16 and TAS2R10 were expressed in HaCaT cells and were upregulated by D-gal treatment. TAS2R16 exerted protective effects against skin aging by regulating p53 and p21, antioxidant enzymes, the SIRT1/mechanistic target of rapamycin pathway, cell migration, and epithelial-mesenchymal transition markers. TAS2R10 was further examined to confirm a role of TAS2R16 in cellular senescence and wound healing in D-gal-induced aged HaCaT cells. CONCLUSIONS: Our results suggest a novel potential preventive role of these receptors on skin aging by regulating cellular senescence and wound healing in human keratinocyte, HaCaT. © 2022 The Korean Nutrition Society and the Korean Society of Community Nutrition.
- DOI
- 10.4162/nrp.2022.16.1.1
- Appears in Collections:
- 신산업융합대학 > 식품영양학과 > Journal papers
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