View : 538 Download: 0
Deoxyvasicinone with Anti-Melanogenic Activity from Marine-Derived Streptomyces sp. CNQ-617
- Title
- Deoxyvasicinone with Anti-Melanogenic Activity from Marine-Derived Streptomyces sp. CNQ-617
- Authors
- Lee S.-E.; Kim M.-J.; Hillman P.F.; Oh D.-C.; Fenical W.; Nam S.-J.; Lim K.-M.
- Ewha Authors
- 임경민; 남상집
- SCOPUS Author ID
- 임경민; 남상집
- Issue Date
- 2022
- Journal Title
- Marine Drugs
- ISSN
- 1660-3397
- Citation
- Marine Drugs vol. 20, no. 2
- Keywords
- Anti-melanogenic effect; Deoxyvasicinone; Marine natural products; Streptomyces sp
- Publisher
- MDPI
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- The tricyclic quinazoline alkaloid deoxyvasicinone (DOV, 1) was isolated from a marinederived Streptomyces sp. CNQ-617, and its anti-melanogenic effects were investigated. Deoxyvasicinone was shown to decrease the melanin content of B16F10 and MNT-1 cells that have been stimulated by α-melanocyte-stimulating hormone (α-MSH). In addition, microscopic images of the cells showed that deoxyvasicinone attenuated melanocyte activation. Although, deoxyvasicinone did not directly inhibit tyrosinase (TYR) enzymatic activity, real-time PCR showed that it inhibited the mRNA expression of TYR, tyrosinase-related protein 1 (TRP-1), and tyrosinase-related protein 2 (TRP-2). In the artificial 3D pigmented skin model Melanoderm™, deoxyvasicinone brightened the skin significantly, as confirmed by histological examination. In conclusion, this study demonstrated that the marine microbial natural product deoxyvascinone has an anti-melanogenic effect through downregulation of melanogenic enzymes. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
- DOI
- 10.3390/md20020155
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML