Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 임경민 | * |
dc.contributor.author | 남상집 | * |
dc.date.accessioned | 2022-03-29T16:31:00Z | - |
dc.date.available | 2022-03-29T16:31:00Z | - |
dc.date.issued | 2022 | * |
dc.identifier.issn | 1660-3397 | * |
dc.identifier.other | OAK-31135 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/260927 | - |
dc.description.abstract | The tricyclic quinazoline alkaloid deoxyvasicinone (DOV, 1) was isolated from a marinederived Streptomyces sp. CNQ-617, and its anti-melanogenic effects were investigated. Deoxyvasicinone was shown to decrease the melanin content of B16F10 and MNT-1 cells that have been stimulated by α-melanocyte-stimulating hormone (α-MSH). In addition, microscopic images of the cells showed that deoxyvasicinone attenuated melanocyte activation. Although, deoxyvasicinone did not directly inhibit tyrosinase (TYR) enzymatic activity, real-time PCR showed that it inhibited the mRNA expression of TYR, tyrosinase-related protein 1 (TRP-1), and tyrosinase-related protein 2 (TRP-2). In the artificial 3D pigmented skin model Melanoderm™, deoxyvasicinone brightened the skin significantly, as confirmed by histological examination. In conclusion, this study demonstrated that the marine microbial natural product deoxyvascinone has an anti-melanogenic effect through downregulation of melanogenic enzymes. © 2022 by the authors. Licensee MDPI, Basel, Switzerland. | * |
dc.language | English | * |
dc.publisher | MDPI | * |
dc.subject | Anti-melanogenic effect | * |
dc.subject | Deoxyvasicinone | * |
dc.subject | Marine natural products | * |
dc.subject | Streptomyces sp | * |
dc.title | Deoxyvasicinone with Anti-Melanogenic Activity from Marine-Derived Streptomyces sp. CNQ-617 | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 20 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | Marine Drugs | * |
dc.identifier.doi | 10.3390/md20020155 | * |
dc.identifier.wosid | WOS:000765097800001 | * |
dc.identifier.scopusid | 2-s2.0-85125194060 | * |
dc.author.google | Lee S.-E. | * |
dc.author.google | Kim M.-J. | * |
dc.author.google | Hillman P.F. | * |
dc.author.google | Oh D.-C. | * |
dc.author.google | Fenical W. | * |
dc.author.google | Nam S.-J. | * |
dc.author.google | Lim K.-M. | * |
dc.contributor.scopusid | 임경민(8916551700) | * |
dc.contributor.scopusid | 남상집(57208839798) | * |
dc.date.modifydate | 20240220115649 | * |