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Effect of Mori ramulus on the postprandial blood glucose levels and inflammatory responses of healthy subjects subjected to an oral high-fat/sucrose challenge: A double-blind, randomized, crossover clinical trial
- Title
- Effect of Mori ramulus on the postprandial blood glucose levels and inflammatory responses of healthy subjects subjected to an oral high-fat/sucrose challenge: A double-blind, randomized, crossover clinical trial
- Authors
- Park S.-Y.; Kwon O.; Kim J.Y.
- Ewha Authors
- 권오란
- SCOPUS Author ID
- 권오란
- Issue Date
- 2022
- Journal Title
- Biomedicine and Pharmacotherapy
- ISSN
- 0753-3322
- Citation
- Biomedicine and Pharmacotherapy vol. 146
- Keywords
- Diabetes mellitus; Glucose metabolism; High-fat/sucrose challenge; Inflammation; Mori ramulus; Morus alba L.
- Publisher
- Elsevier Masson s.r.l.
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Blood glucose is inadequately controlled in diabetes mellitus, causing various inflammation-related complications. This study aimed to investigate responses to an oral sucrose/lipid challenge in the context of glucose metabolism after consumption of Mori ramulus (MR) extract. In this study on healthy subjects, the optimal dose and safety of MR were confirmed in a preliminary pilot trial (n = 24), meanwhile, blood glucose, insulin, and inflammatory marker levels were detected via an oral sucrose/lipid tolerance test in the main trial (n = 36). In the main study, the blood glucose response was significantly decreased after 240 min in the MR group. Compared to the placebo group, the treatment group exhibited plasma insulin levels that were significantly increased at 120 min and decreased at 240 min. In conclusion, a single MR extract dose protects against inflammation induced by high-fat/sugar to maintain normal insulin secretion and thus helps to maintain postprandial blood glucose levels via an inflammatory mechanism. © 2021
- DOI
- 10.1016/j.biopha.2021.112552
- Appears in Collections:
- 신산업융합대학 > 식품영양학과 > Journal papers
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