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Resveratrol-beta-Lactoglobulin Composite Nanocoating by Layer-by-Layer Assembly with Fe(III)-Tannic Acid Complex
- Title
- Resveratrol-beta-Lactoglobulin Composite Nanocoating by Layer-by-Layer Assembly with Fe(III)-Tannic Acid Complex
- Authors
- Cho, Yeon Seo; Kim, Seulbi; Kim, Young-Kwan; Jin, Sung Giu; Park, Ji Hun
- Ewha Authors
- 박지훈
- SCOPUS Author ID
- 박지훈
- Issue Date
- 2021
- Journal Title
- CHEMISTRY-AN ASIAN JOURNAL
- ISSN
- 1861-4728
1861-471X
- Citation
- CHEMISTRY-AN ASIAN JOURNAL vol. 16, no. 22, pp. 3636 - 3639
- Keywords
- Resveratrol; beta-Lactoglobulin; Tannic acid; Nanostructures; Thin films
- Publisher
- WILEY-V C H VERLAG GMBH
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Resveratrol (3,4',5-trihydroxystilbene) is beneficial to human health due to its diverse biological activities including its anti-inflammatory and anti-oxidative effects as confirmed by pharmacokinetic tests. Despite these clinical merits, resveratrol's limited hydrosolubility and chemical vulnerability remain challenging with regard to developing a controlled delivery system with enhanced bioavailability. In this work, we report a resveratrol-beta-lactoglobulin (R-BLG) composite nanocoating through a layer-by-layer assembly with Fe(III)-tannic acid nanofilms. The R-BLG composite nanocoating can be formed in planar and particulate substrates, showing excellent film stability under a broad range of pH values and against enzymatic digestion during a weeklong incubation. We envision that the proteinaceous nanocoating herein could be combined with existing pharmaceutical carrier materials (e. g., microcapsules and nanoparticles) to realize advanced drug delivery systems with an expanded repertoire of hydrophobic drugs.
- DOI
- 10.1002/asia.202100923
- Appears in Collections:
- 사범대학 > 과학교육과 > Journal papers
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