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Protein-Activatable Diarylethene Monomer as a Smart Trigger of Noninvasive Control Over Reversible Generation of Singlet Oxygen: A Facile, Switchable, Theranostic Strategy for Photodynamic-Immunotherapy
- Title
- Protein-Activatable Diarylethene Monomer as a Smart Trigger of Noninvasive Control Over Reversible Generation of Singlet Oxygen: A Facile, Switchable, Theranostic Strategy for Photodynamic-Immunotherapy
- Authors
- Cheng, Hong-Bo; Qiao, Bin; Li, Hao; Cao, Jin; Luo, Yuanli; Swamy, Kunemadihalli Mathada Kotraiah; Zhao, Jing; Wang, Zhigang; Lee, Jin Yong; Liang, Xing-Jie; Yoon, Juyoung
- Ewha Authors
- 윤주영; K.M.K Swamy
- SCOPUS Author ID
- 윤주영; K.M.K Swamy
- Issue Date
- 2021
- Journal Title
- JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- ISSN
- 0002-7863
1520-5126
- Citation
- JOURNAL OF THE AMERICAN CHEMICAL SOCIETY vol. 143, no. 5, pp. 2413 - 2422
- Publisher
- AMER CHEMICAL SOC
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- The development of activatable photosensitizers to allow for the reversible control of singlet oxygen (O-1(2)) production for photodynamic therapy (PDT) faces great challenges. Fortunately, the flourishing field of supramolecular biotechnology provides more effective strategies for activatable PDT systems. Here, we developed a new reversible PDT on a switch that controls the O-1(2) generation of self-assembled albumin nanotheranostics in vitro and in vivo. A new molecular design principle of aggregation-induced self-quenching photochromism and albumin on-photoswitching was demonstrated using a new asymmetric, synthetic diarylethene moiety DIA. The photosensitizer porphyrin and DIA were incorporated as building blocks in a glutaraldehyde-induced covalent albumin cross-linking nanoplatform, HSA-DIA-porphyrin nanoparticles (NPs). More importantly, the excellent photoswitching property of DIA enables the resultant nanoplatform to act as a facile, switchable strategy for photodynamic-immunotherapy.
- DOI
- 10.1021/jacs.0c12851
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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