Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤주영 | * |
dc.contributor.author | K.M.K Swamy | * |
dc.date.accessioned | 2021-05-28T16:30:59Z | - |
dc.date.available | 2021-05-28T16:30:59Z | - |
dc.date.issued | 2021 | * |
dc.identifier.issn | 0002-7863 | * |
dc.identifier.issn | 1520-5126 | * |
dc.identifier.other | OAK-29079 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/257465 | - |
dc.description.abstract | The development of activatable photosensitizers to allow for the reversible control of singlet oxygen (O-1(2)) production for photodynamic therapy (PDT) faces great challenges. Fortunately, the flourishing field of supramolecular biotechnology provides more effective strategies for activatable PDT systems. Here, we developed a new reversible PDT on a switch that controls the O-1(2) generation of self-assembled albumin nanotheranostics in vitro and in vivo. A new molecular design principle of aggregation-induced self-quenching photochromism and albumin on-photoswitching was demonstrated using a new asymmetric, synthetic diarylethene moiety DIA. The photosensitizer porphyrin and DIA were incorporated as building blocks in a glutaraldehyde-induced covalent albumin cross-linking nanoplatform, HSA-DIA-porphyrin nanoparticles (NPs). More importantly, the excellent photoswitching property of DIA enables the resultant nanoplatform to act as a facile, switchable strategy for photodynamic-immunotherapy. | * |
dc.language | English | * |
dc.publisher | AMER CHEMICAL SOC | * |
dc.title | Protein-Activatable Diarylethene Monomer as a Smart Trigger of Noninvasive Control Over Reversible Generation of Singlet Oxygen: A Facile, Switchable, Theranostic Strategy for Photodynamic-Immunotherapy | * |
dc.type | Article | * |
dc.relation.issue | 5 | * |
dc.relation.volume | 143 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 2413 | * |
dc.relation.lastpage | 2422 | * |
dc.relation.journaltitle | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | * |
dc.identifier.doi | 10.1021/jacs.0c12851 | * |
dc.identifier.wosid | WOS:000619637300031 | * |
dc.identifier.scopusid | 2-s2.0-85100667776 | * |
dc.author.google | Cheng, Hong-Bo | * |
dc.author.google | Qiao, Bin | * |
dc.author.google | Li, Hao | * |
dc.author.google | Cao, Jin | * |
dc.author.google | Luo, Yuanli | * |
dc.author.google | Swamy, Kunemadihalli Mathada Kotraiah | * |
dc.author.google | Zhao, Jing | * |
dc.author.google | Wang, Zhigang | * |
dc.author.google | Lee, Jin Yong | * |
dc.author.google | Liang, Xing-Jie | * |
dc.author.google | Yoon, Juyoung | * |
dc.contributor.scopusid | 윤주영(7403587371) | * |
dc.contributor.scopusid | K.M.K Swamy(8384468700) | * |
dc.date.modifydate | 20240118162450 | * |