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Urinary Metabolomic Profiling Analysis and Evaluation of the Effect ofEcklonia cavaExtract Intake
- Title
- Urinary Metabolomic Profiling Analysis and Evaluation of the Effect ofEcklonia cavaExtract Intake
- Authors
- Kim, Juyeon; Jung, Youngae; Lee, Eunok; Jang, Seoyeong; Ryu, Do Hyun; Kwon, Oran; Hwang, Geum-Sook
- Ewha Authors
- 권오란; 황금숙
- SCOPUS Author ID
- 권오란; 황금숙
- Issue Date
- 2020
- Journal Title
- NUTRIENTS
- ISSN
- 2072-6643
- Citation
- NUTRIENTS vol. 12, no. 5
- Keywords
- Ecklonia cava; seapolynol; metabolomics; antioxidant effect; mass spectrometry
- Publisher
- MDPI
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Metabolomics is a powerful tool for the investigation of interactions between diet, nutrients, and human metabolism.Ecklonia cavais an edible brown alga that is abundantly found in Korea and Japan and contains unique polyphenols referred to as phlorotannins. However, there are few metabolomics studies related to the effects of polyphenols in humans. In this study, we performed a mass spectrometry-based metabolomics analysis of urine samples from participants with a body mass index (BMI) higher than 25 kg/m(2)and lower than 30 kg/m(2)to investigate the effects of the intake of seapolynol isolated fromE. cava. Metabolomic profiling showed that the levels of riboflavin, urocanic acid, 5-hydroxy-6-methoxyindole glucuronide, and guanidino valeric acid were significantly increased in the seapolynol intake group compared with the placebo group. A correlation analysis was performed to identify the association between the metabolites' levels and clinical characteristics related to body fat. Among the metabolites whose concentrations changed in the seapolynol intake group, riboflavin was associated with BMI, body weight, fat mass, and percent body fat. These findings suggest that the decreased body fat induced by the intake of seapolynol is related to an increase in the antioxidant effect of riboflavin.
- DOI
- 10.3390/nu12051407
- Appears in Collections:
- 신산업융합대학 > 식품영양학과 > Journal papers
- Files in This Item:
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nutrients-12-01407.pdf(1.44 MB)
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