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Ubiquitin-proteasome system (UPS) as a target for anticancer treatment
- Title
- Ubiquitin-proteasome system (UPS) as a target for anticancer treatment
- Authors
- Park, Jinyoung; Cho, Jinhong; Song, Eun Joo
- Ewha Authors
- 송은주
- SCOPUS Author ID
- 송은주
- Issue Date
- 2020
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- ISSN
- 0253-6269
1976-3786
- Citation
- ARCHIVES OF PHARMACAL RESEARCH vol. 43, no. 11, pp. 1144 - 1161
- Keywords
- Ubiquitin– proteasome system (UPS); E3 ligase; Deubiquitinating enzymes (DUBs); Proteasome; Cancer; Small molecule inhibitors
- Publisher
- PHARMACEUTICAL SOC KOREA
- Indexed
- SCIE; SCOPUS; KCI
- Document Type
- Review
- Abstract
- The ubiquitin-proteasome system (UPS) plays an important role in the cellular processes for protein quality control and homeostasis. Dysregulation of the UPS has been implicated in numerous diseases, including cancer. Indeed, components of UPS are frequently mutated or abnormally expressed in various cancers. Since Bortezomib, a proteasome inhibitor, received FDA approval for the treatment of multiple myeloma and mantle cell lymphoma, increasing numbers of researchers have been seeking drugs targeting the UPS as a cancer therapeutic strategy. Here, we introduce the essential component of UPS, including ubiquitinating enzymes, deubiquitinating enzymes and 26S proteasome, and we summarize their targets and mechanisms that are crucial for tumorigenesis. In addition, we briefly discuss some UPS inhibitors, which are currently in clinical trials as cancer therapeutics.
- DOI
- 10.1007/s12272-020-01281-8
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
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