Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 송은주 | * |
dc.date.accessioned | 2021-01-07T16:30:01Z | - |
dc.date.available | 2021-01-07T16:30:01Z | - |
dc.date.issued | 2020 | * |
dc.identifier.issn | 0253-6269 | * |
dc.identifier.issn | 1976-3786 | * |
dc.identifier.other | OAK-28552 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/255912 | - |
dc.description.abstract | The ubiquitin-proteasome system (UPS) plays an important role in the cellular processes for protein quality control and homeostasis. Dysregulation of the UPS has been implicated in numerous diseases, including cancer. Indeed, components of UPS are frequently mutated or abnormally expressed in various cancers. Since Bortezomib, a proteasome inhibitor, received FDA approval for the treatment of multiple myeloma and mantle cell lymphoma, increasing numbers of researchers have been seeking drugs targeting the UPS as a cancer therapeutic strategy. Here, we introduce the essential component of UPS, including ubiquitinating enzymes, deubiquitinating enzymes and 26S proteasome, and we summarize their targets and mechanisms that are crucial for tumorigenesis. In addition, we briefly discuss some UPS inhibitors, which are currently in clinical trials as cancer therapeutics. | * |
dc.language | English | * |
dc.publisher | PHARMACEUTICAL SOC KOREA | * |
dc.subject | Ubiquitin&#8211 | * |
dc.subject | proteasome system (UPS) | * |
dc.subject | E3 ligase | * |
dc.subject | Deubiquitinating enzymes (DUBs) | * |
dc.subject | Proteasome | * |
dc.subject | Cancer | * |
dc.subject | Small molecule inhibitors | * |
dc.title | Ubiquitin-proteasome system (UPS) as a target for anticancer treatment | * |
dc.type | Review | * |
dc.relation.issue | 11 | * |
dc.relation.volume | 43 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 1144 | * |
dc.relation.lastpage | 1161 | * |
dc.relation.journaltitle | ARCHIVES OF PHARMACAL RESEARCH | * |
dc.identifier.doi | 10.1007/s12272-020-01281-8 | * |
dc.identifier.wosid | WOS:000588005000001 | * |
dc.identifier.scopusid | 2-s2.0-85095605596 | * |
dc.author.google | Park, Jinyoung | * |
dc.author.google | Cho, Jinhong | * |
dc.author.google | Song, Eun Joo | * |
dc.contributor.scopusid | 송은주(7101904210) | * |
dc.date.modifydate | 20240311110828 | * |