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A fluorescent ESIPT-based benzimidazole platform for the ratiometric two-photon imaging of ONOO(-)in vitroandex vivo

Title
A fluorescent ESIPT-based benzimidazole platform for the ratiometric two-photon imaging of ONOO(-)in vitroandex vivo
Authors
Odyniec, Maria L.Park, Sang-JunGardiner, Jordan E.Webb, Emily C.Sedgwick, Adam C.Yoon, JuyoungBull, Steven D.Kim, Hwan MyungJames, Tony D.
Ewha Authors
윤주영
SCOPUS Author ID
윤주영scopus
Issue Date
2020
Journal Title
CHEMICAL SCIENCE
ISSN
2041-6520JCR Link

2041-6539JCR Link
Citation
CHEMICAL SCIENCE vol. 11, no. 28, pp. 7329 - 7334
Publisher
ROYAL SOC CHEMISTRY
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
In this work, we have developed an ESIPT-based benzimidazole platform (MO-E1andMO-E2) for the two-photon cell imaging of ONOO(-)and a potential ONOO--activated theranostic scaffold (MO-E3). Each benzimidazole platform,MO-E1-3, were shown to rapidly detect ONOO(-)at micromolar concentrations (LoD = 0.28 mu M, 6.53 mu M and 0.81 mu M respectively). The potential theranosticMO-E3was shown to release the parent fluorophore and drug indomethacin in the presence of ONOO(-)but unfortunately did not perform wellin vitrodue to low solubility. Despite this, the parent scaffoldMO-E2demonstrated its effectiveness as a two-photon imaging tool for the ratiometric detection of endogenous ONOO(-)in RAW264.7 macrophages and rat hippocampus tissue. These results demonstrate the utility of this ESIPT benzimidazole-based platform for theranostic development and bioimaging applications.
DOI
10.1039/d0sc02347g
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자연과학대학 > 화학·나노과학전공 > Journal papers
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