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dc.contributor.author윤주영*
dc.date.accessioned2020-08-20T16:30:25Z-
dc.date.available2020-08-20T16:30:25Z-
dc.date.issued2020*
dc.identifier.issn2041-6520*
dc.identifier.issn2041-6539*
dc.identifier.otherOAK-27350*
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/255083-
dc.description.abstractIn this work, we have developed an ESIPT-based benzimidazole platform (MO-E1andMO-E2) for the two-photon cell imaging of ONOO(-)and a potential ONOO--activated theranostic scaffold (MO-E3). Each benzimidazole platform,MO-E1-3, were shown to rapidly detect ONOO(-)at micromolar concentrations (LoD = 0.28 mu M, 6.53 mu M and 0.81 mu M respectively). The potential theranosticMO-E3was shown to release the parent fluorophore and drug indomethacin in the presence of ONOO(-)but unfortunately did not perform wellin vitrodue to low solubility. Despite this, the parent scaffoldMO-E2demonstrated its effectiveness as a two-photon imaging tool for the ratiometric detection of endogenous ONOO(-)in RAW264.7 macrophages and rat hippocampus tissue. These results demonstrate the utility of this ESIPT benzimidazole-based platform for theranostic development and bioimaging applications.*
dc.languageEnglish*
dc.publisherROYAL SOC CHEMISTRY*
dc.titleA fluorescent ESIPT-based benzimidazole platform for the ratiometric two-photon imaging of ONOO(-)in vitroandex vivo*
dc.typeArticle*
dc.relation.issue28*
dc.relation.volume11*
dc.relation.indexSCIE*
dc.relation.indexSCOPUS*
dc.relation.startpage7329*
dc.relation.lastpage7334*
dc.relation.journaltitleCHEMICAL SCIENCE*
dc.identifier.doi10.1039/d0sc02347g*
dc.identifier.wosidWOS:000550969100003*
dc.author.googleOdyniec, Maria L.*
dc.author.googlePark, Sang-Jun*
dc.author.googleGardiner, Jordan E.*
dc.author.googleWebb, Emily C.*
dc.author.googleSedgwick, Adam C.*
dc.author.googleYoon, Juyoung*
dc.author.googleBull, Steven D.*
dc.author.googleKim, Hwan Myung*
dc.author.googleJames, Tony D.*
dc.contributor.scopusid윤주영(7403587371)*
dc.date.modifydate20240118162450*
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자연과학대학 > 화학·나노과학전공 > Journal papers
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