Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤주영 | * |
dc.date.accessioned | 2020-08-20T16:30:25Z | - |
dc.date.available | 2020-08-20T16:30:25Z | - |
dc.date.issued | 2020 | * |
dc.identifier.issn | 2041-6520 | * |
dc.identifier.issn | 2041-6539 | * |
dc.identifier.other | OAK-27350 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/255083 | - |
dc.description.abstract | In this work, we have developed an ESIPT-based benzimidazole platform (MO-E1andMO-E2) for the two-photon cell imaging of ONOO(-)and a potential ONOO--activated theranostic scaffold (MO-E3). Each benzimidazole platform,MO-E1-3, were shown to rapidly detect ONOO(-)at micromolar concentrations (LoD = 0.28 mu M, 6.53 mu M and 0.81 mu M respectively). The potential theranosticMO-E3was shown to release the parent fluorophore and drug indomethacin in the presence of ONOO(-)but unfortunately did not perform wellin vitrodue to low solubility. Despite this, the parent scaffoldMO-E2demonstrated its effectiveness as a two-photon imaging tool for the ratiometric detection of endogenous ONOO(-)in RAW264.7 macrophages and rat hippocampus tissue. These results demonstrate the utility of this ESIPT benzimidazole-based platform for theranostic development and bioimaging applications. | * |
dc.language | English | * |
dc.publisher | ROYAL SOC CHEMISTRY | * |
dc.title | A fluorescent ESIPT-based benzimidazole platform for the ratiometric two-photon imaging of ONOO(-)in vitroandex vivo | * |
dc.type | Article | * |
dc.relation.issue | 28 | * |
dc.relation.volume | 11 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 7329 | * |
dc.relation.lastpage | 7334 | * |
dc.relation.journaltitle | CHEMICAL SCIENCE | * |
dc.identifier.doi | 10.1039/d0sc02347g | * |
dc.identifier.wosid | WOS:000550969100003 | * |
dc.author.google | Odyniec, Maria L. | * |
dc.author.google | Park, Sang-Jun | * |
dc.author.google | Gardiner, Jordan E. | * |
dc.author.google | Webb, Emily C. | * |
dc.author.google | Sedgwick, Adam C. | * |
dc.author.google | Yoon, Juyoung | * |
dc.author.google | Bull, Steven D. | * |
dc.author.google | Kim, Hwan Myung | * |
dc.author.google | James, Tony D. | * |
dc.contributor.scopusid | 윤주영(7403587371) | * |
dc.date.modifydate | 20240118162450 | * |