Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 박지훈 | * |
dc.date.accessioned | 2020-08-13T16:30:08Z | - |
dc.date.available | 2020-08-13T16:30:08Z | - |
dc.date.issued | 2020 | * |
dc.identifier.issn | 1744-683X | * |
dc.identifier.issn | 1744-6848 | * |
dc.identifier.other | OAK-27283 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/254907 | - |
dc.description.abstract | The build-up and degradation of cytocompatible nanofilms in a controlled fashion have great potential in biomedical and nanomedicinal fields, including single-cell nanoencapsulation (SCNE). Herein, we report the fabrication of biodegradable films of cationic starch (c-ST) and anionic alginate (ALG) by electrostatically driven layer-by-layer (LbL) assembly technology and its application to the SCNE. The [c-ST/ALG] multilayer nanofilms, assembled either on individual Saccharomyces cerevisiae or on the 2D flat gold surface, degrade on demand, in a cytocompatible fashion, via treatment with alpha-amylase. Their degradation profiles are investigated, while systematically changing the alpha-amylase concentration, by several surface characterization techniques, including quartz crystal microbalance with dissipation monitoring (QCM-D) and ellipsometry. DNA incorporation in the LbL nanofilms and its controlled release, upon exposure of the nanofilms to an aqueous alpha-amylase solution, are demonstrated. The highly cytocompatible nature of the film-forming and -degrading conditions is assessed in the c-ST/ALG-shell formation and degradation of S. cerevisiae. We envisage that the cytocompatible, enzymatic degradation of c-ST-based nanofilms paves the way for developing advanced biomedical devices with programmed dissolution in vivo. | * |
dc.language | English | * |
dc.publisher | ROYAL SOC CHEMISTRY | * |
dc.title | Enzymatically degradable, starch-based layer-by-layer films: application to cytocompatible single-cell nanoencapsulation | * |
dc.type | Article | * |
dc.relation.issue | 26 | * |
dc.relation.volume | 16 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 6063 | * |
dc.relation.lastpage | 6071 | * |
dc.relation.journaltitle | SOFT MATTER | * |
dc.identifier.doi | 10.1039/d0sm00876a | * |
dc.identifier.wosid | WOS:000552440400021 | * |
dc.identifier.scopusid | 2-s2.0-85088211200 | * |
dc.author.google | Moon, Hee Chul | * |
dc.author.google | Han, Sol | * |
dc.author.google | Borges, Joao | * |
dc.author.google | Pesqueira, Tamagno | * |
dc.author.google | Choi, Hyunwoo | * |
dc.author.google | Han, Sang Yeong | * |
dc.author.google | Cho, Hyeoncheol | * |
dc.author.google | Park, Ji Hun | * |
dc.author.google | Mano, Joao F. | * |
dc.author.google | Choi, Insung S. | * |
dc.contributor.scopusid | 박지훈(57202217665) | * |
dc.date.modifydate | 20240308130150 | * |