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Inhibitory Effects of Furanocoumarins From the Roots of Angelica dahurica on Ionizing Radiation-Induced Migration of A549 Human Non-Small Cell Lung Cancer Cells
- Title
- Inhibitory Effects of Furanocoumarins From the Roots of Angelica dahurica on Ionizing Radiation-Induced Migration of A549 Human Non-Small Cell Lung Cancer Cells
- Authors
- Lee, Sang Hoon; Han, Ah-Reum; Kang, Unwoo; Kim, Jin-Baek; Seo, Eun Kyoung; Jung, Chan-Hun
- Ewha Authors
- 서은경
- SCOPUS Author ID
- 서은경
- Issue Date
- 2020
- Journal Title
- NATURAL PRODUCT COMMUNICATIONS
- ISSN
- 1934-578X
1555-9475
- Citation
- NATURAL PRODUCT COMMUNICATIONS vol. 15, no. 4
- Keywords
- Angelica dahurica; apiaceae; furanocoumarin; radiation-induced migration; non-small-cell lung cancer cells
- Publisher
- SAGE PUBLICATIONS INC
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Radiation therapy is a very effective tool for the treatment of advanced human lung cancers. However, as one of its malignancy-promoting behaviors, ionizing radiation (IR) increases cell migration and radiation resistance in several lung cancer cells, including non-small cell lung cancer (NSCLC) cells. As part of our ongoing search for potent radiotherapy enhancers from medicinal herbs, a chloroform-soluble fraction of the roots of Angelica dahurica was subjected to phytochemical investigation, leading to the isolation of 8 furanocoumarins. Of these, psoralen (1), xanthotoxin (2), and bergapten (3) inhibited IR-induced migration at a non-cytotoxic concentration (50 mu M) in human NSCLC A549 cells. This study is the first to report on the inhibitory activities of these constituents of A. dahurica against IR-induced cancer metastasis.
- DOI
- 10.1177/1934578X20915036
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
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