Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 서은경 | * |
dc.date.accessioned | 2020-06-08T16:30:15Z | - |
dc.date.available | 2020-06-08T16:30:15Z | - |
dc.date.issued | 2020 | * |
dc.identifier.issn | 1934-578X | * |
dc.identifier.issn | 1555-9475 | * |
dc.identifier.other | OAK-26982 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/254038 | - |
dc.description.abstract | Radiation therapy is a very effective tool for the treatment of advanced human lung cancers. However, as one of its malignancy-promoting behaviors, ionizing radiation (IR) increases cell migration and radiation resistance in several lung cancer cells, including non-small cell lung cancer (NSCLC) cells. As part of our ongoing search for potent radiotherapy enhancers from medicinal herbs, a chloroform-soluble fraction of the roots of Angelica dahurica was subjected to phytochemical investigation, leading to the isolation of 8 furanocoumarins. Of these, psoralen (1), xanthotoxin (2), and bergapten (3) inhibited IR-induced migration at a non-cytotoxic concentration (50 mu M) in human NSCLC A549 cells. This study is the first to report on the inhibitory activities of these constituents of A. dahurica against IR-induced cancer metastasis. | * |
dc.language | English | * |
dc.publisher | SAGE PUBLICATIONS INC | * |
dc.subject | Angelica dahurica | * |
dc.subject | apiaceae | * |
dc.subject | furanocoumarin | * |
dc.subject | radiation-induced migration | * |
dc.subject | non-small-cell lung cancer cells | * |
dc.title | Inhibitory Effects of Furanocoumarins From the Roots of Angelica dahurica on Ionizing Radiation-Induced Migration of A549 Human Non-Small Cell Lung Cancer Cells | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 15 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | NATURAL PRODUCT COMMUNICATIONS | * |
dc.identifier.doi | 10.1177/1934578X20915036 | * |
dc.identifier.wosid | WOS:000529085900001 | * |
dc.author.google | Lee, Sang Hoon | * |
dc.author.google | Han, Ah-Reum | * |
dc.author.google | Kang, Unwoo | * |
dc.author.google | Kim, Jin-Baek | * |
dc.author.google | Seo, Eun Kyoung | * |
dc.author.google | Jung, Chan-Hun | * |
dc.contributor.scopusid | 서은경(7005953758) | * |
dc.date.modifydate | 20240118144717 | * |