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Coffee Melanoidin-Based Multipurpose Film Formation: Application to Single-Cell Nanoencapsulation
- Title
- Coffee Melanoidin-Based Multipurpose Film Formation: Application to Single-Cell Nanoencapsulation
- Authors
- Kim J.Y.; Kim S.; Han S.; Han S.Y.; Passos C.P.; Seo J.; Lee H.; Kang E.K.; Mano J.F.; Coimbra M.A.; Park J.H.; Choi I.S.
- Ewha Authors
- 박지훈
- SCOPUS Author ID
- 박지훈
- Issue Date
- 2020
- Journal Title
- ChemNanoMat
- ISSN
- 2199-692X
- Citation
- ChemNanoMat vol. 6, no. 3, pp. 379 - 385
- Keywords
- carbohydrates; cell encapsulation; coffee melanoidin; film formation; surface engineering
- Publisher
- Wiley-VCH Verlag
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- The melanoidin from soluble coffee is utilized as a material-independent, multipurpose coating material. Instantaneous complexation of the coffee melanoidin (CM) with ferric ion (Fe3+) leads to surface-adhesive aggregates, inducing sequential film deposition. Various chemical groups of the CM also allow for post-functionalizations of the CM film, including surface-initiated, ring-opening polymerization and bioinspired silicification. In addition, the CM-based coating is applied to single-cell nanoencapsulation with a strategy of biphasic interfacial reactions. The method is highly cytocompatible (viability >98%), and the CM shell is cytoprotective against lytic enzymes. The coated cells inherit the characterictics of the CM, such as post-functionalizability and antioxidant property. Considering that surface-coating technologies with cytocompatible natural polymers have widely been used for engineering bioentities, the CM-based coating strategy would provide an advanced option for biomedical applications. © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
- DOI
- 10.1002/cnma.202000004
- Appears in Collections:
- 사범대학 > 과학교육과 > Journal papers
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