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Peptide-Driven Shape Control of Low-Dimensional DNA Nanostructures

Title
Peptide-Driven Shape Control of Low-Dimensional DNA Nanostructures
Authors
Kim C.-J.Park J.-E.Hu X.Albert S.K.Park S.-J.
Ewha Authors
박소정박지은김찬진
SCOPUS Author ID
박소정scopus; 박지은scopus; 김찬진scopus
Issue Date
2020
Journal Title
ACS Nano
ISSN
1936-0851JCR Link
Citation
ACS Nano vol. 14, no. 2, pp. 2276 - 2284
Keywords
block copolymerDNAnanofibernanosheetpeptideself-assembly
Publisher
American Chemical Society
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
We report the rational design and fabrication of unusual low-dimensional DNA nanostructures through programmable and sequence-specific peptide interactions. Dual-bioactive block copolymers composed of DNA and amino acid-based polymers (DNA-b-poly(amino acid)) were synthesized by coupling oligonucleotides to phenylalanine (Phe)-based polymers. Unlike prototypical DNA block copolymers, which typically form simple spherical micelles, DNA-b-poly(amino acid) assemble into various low-dimensional structures such as nanofibers, ribbons, and sheets through controllable amino acid interactions. Moreover, DNA-b-poly(amino acid) assemblies can undergo protease-induced fiber-to-sheet shape transformations, where the morphology change is dictated by the type of enzymes and amino acid sequences. The peptide-based self-assembly reported here provides a programmable approach to fabricate dynamic DNA assemblies with diverse and unusual low-dimensional structures. © 2020 American Chemical Society.
DOI
10.1021/acsnano.9b09312
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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