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dc.contributor.author박소정-
dc.contributor.author박지은-
dc.contributor.author김찬진-
dc.date.accessioned2020-04-06T16:30:09Z-
dc.date.available2020-04-06T16:30:09Z-
dc.date.issued2020-
dc.identifier.issn1936-0851-
dc.identifier.otherOAK-26669-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/253728-
dc.description.abstractWe report the rational design and fabrication of unusual low-dimensional DNA nanostructures through programmable and sequence-specific peptide interactions. Dual-bioactive block copolymers composed of DNA and amino acid-based polymers (DNA-b-poly(amino acid)) were synthesized by coupling oligonucleotides to phenylalanine (Phe)-based polymers. Unlike prototypical DNA block copolymers, which typically form simple spherical micelles, DNA-b-poly(amino acid) assemble into various low-dimensional structures such as nanofibers, ribbons, and sheets through controllable amino acid interactions. Moreover, DNA-b-poly(amino acid) assemblies can undergo protease-induced fiber-to-sheet shape transformations, where the morphology change is dictated by the type of enzymes and amino acid sequences. The peptide-based self-assembly reported here provides a programmable approach to fabricate dynamic DNA assemblies with diverse and unusual low-dimensional structures. © 2020 American Chemical Society.-
dc.languageEnglish-
dc.publisherAmerican Chemical Society-
dc.subjectblock copolymer-
dc.subjectDNA-
dc.subjectnanofiber-
dc.subjectnanosheet-
dc.subjectpeptide-
dc.subjectself-assembly-
dc.titlePeptide-Driven Shape Control of Low-Dimensional DNA Nanostructures-
dc.typeArticle-
dc.relation.issue2-
dc.relation.volume14-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage2276-
dc.relation.lastpage2284-
dc.relation.journaltitleACS Nano-
dc.identifier.doi10.1021/acsnano.9b09312-
dc.identifier.wosidWOS:000518024700094-
dc.identifier.scopusid2-s2.0-85081175108-
dc.author.googleKim C.-J.-
dc.author.googlePark J.-E.-
dc.author.googleHu X.-
dc.author.googleAlbert S.K.-
dc.author.googlePark S.-J.-
dc.contributor.scopusid박소정(7501832353)-
dc.contributor.scopusid박지은(35103255000)-
dc.contributor.scopusid김찬진(57192071653)-
dc.date.modifydate20201102081004-
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