Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박소정 | * |
dc.contributor.author | 박지은 | * |
dc.contributor.author | 김찬진 | * |
dc.date.accessioned | 2020-04-06T16:30:09Z | - |
dc.date.available | 2020-04-06T16:30:09Z | - |
dc.date.issued | 2020 | * |
dc.identifier.issn | 1936-0851 | * |
dc.identifier.other | OAK-26669 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/253728 | - |
dc.description.abstract | We report the rational design and fabrication of unusual low-dimensional DNA nanostructures through programmable and sequence-specific peptide interactions. Dual-bioactive block copolymers composed of DNA and amino acid-based polymers (DNA-b-poly(amino acid)) were synthesized by coupling oligonucleotides to phenylalanine (Phe)-based polymers. Unlike prototypical DNA block copolymers, which typically form simple spherical micelles, DNA-b-poly(amino acid) assemble into various low-dimensional structures such as nanofibers, ribbons, and sheets through controllable amino acid interactions. Moreover, DNA-b-poly(amino acid) assemblies can undergo protease-induced fiber-to-sheet shape transformations, where the morphology change is dictated by the type of enzymes and amino acid sequences. The peptide-based self-assembly reported here provides a programmable approach to fabricate dynamic DNA assemblies with diverse and unusual low-dimensional structures. © 2020 American Chemical Society. | * |
dc.language | English | * |
dc.publisher | American Chemical Society | * |
dc.subject | block copolymer | * |
dc.subject | DNA | * |
dc.subject | nanofiber | * |
dc.subject | nanosheet | * |
dc.subject | peptide | * |
dc.subject | self-assembly | * |
dc.title | Peptide-Driven Shape Control of Low-Dimensional DNA Nanostructures | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 14 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 2276 | * |
dc.relation.lastpage | 2284 | * |
dc.relation.journaltitle | ACS Nano | * |
dc.identifier.doi | 10.1021/acsnano.9b09312 | * |
dc.identifier.wosid | WOS:000518024700094 | * |
dc.identifier.scopusid | 2-s2.0-85081175108 | * |
dc.author.google | Kim C.-J. | * |
dc.author.google | Park J.-E. | * |
dc.author.google | Hu X. | * |
dc.author.google | Albert S.K. | * |
dc.author.google | Park S.-J. | * |
dc.contributor.scopusid | 박소정(7501832353) | * |
dc.contributor.scopusid | 박지은(57208699898;22836257900) | * |
dc.contributor.scopusid | 김찬진(57192071653) | * |
dc.date.modifydate | 20240429141156 | * |