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Development of Non-Immunosuppressive FK506 Derivatives as Antifungal and Neurotrophic Agents

Title
Development of Non-Immunosuppressive FK506 Derivatives as Antifungal and Neurotrophic Agents
Authors
Jung, Jin A.Yoon, Yeo Joon
Ewha Authors
윤여준
SCOPUS Author ID
윤여준scopus
Issue Date
2020
Journal Title
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
ISSN
1017-7825JCR Link

1738-8872JCR Link
Citation
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY vol. 30, no. 1, pp. 1 - 10
Keywords
FK506biosynthesisantifungal activityneurotrophic activity
Publisher
KOREAN SOC MICROBIOLOGY &

BIOTECHNOLOGY
Indexed
SCIE; SCOPUS; KCI WOS scopus
Document Type
Review
Abstract
FK506, also known as tacrolimus, is a clinically important immunosuppressant drug and has promising therapeutic potentials owing to its antifungal, neuroprotective, and neuroregenerative activities. To generate various FK506 derivatives, the structure of FK506 has been modified by chemical methods or biosynthetic pathway engineering. Herein, we describe the mode of the antifungal action of FK506 and the structure-activity relationship of FK506 derivatives in the context of immunosuppressive and antifungal activities. In addition, we discuss the neurotrophic mechanism of FK506 known to date, along with the neurotrophic FK506 derivatives with significantly reduced immunosuppressive activity. This review suggests the possibility to generate novel FK506 derivatives as antifungal as well as neuroregenerative/neuroprotective agents.
DOI
10.4014/jmb.1911.11008
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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