Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤여준 | - |
dc.date.accessioned | 2020-02-07T16:30:04Z | - |
dc.date.available | 2020-02-07T16:30:04Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 1017-7825 | - |
dc.identifier.issn | 1738-8872 | - |
dc.identifier.other | OAK-26451 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/253297 | - |
dc.description.abstract | FK506, also known as tacrolimus, is a clinically important immunosuppressant drug and has promising therapeutic potentials owing to its antifungal, neuroprotective, and neuroregenerative activities. To generate various FK506 derivatives, the structure of FK506 has been modified by chemical methods or biosynthetic pathway engineering. Herein, we describe the mode of the antifungal action of FK506 and the structure-activity relationship of FK506 derivatives in the context of immunosuppressive and antifungal activities. In addition, we discuss the neurotrophic mechanism of FK506 known to date, along with the neurotrophic FK506 derivatives with significantly reduced immunosuppressive activity. This review suggests the possibility to generate novel FK506 derivatives as antifungal as well as neuroregenerative/neuroprotective agents. | - |
dc.language | English | - |
dc.publisher | KOREAN SOC MICROBIOLOGY & | - |
dc.publisher | BIOTECHNOLOGY | - |
dc.subject | FK506 | - |
dc.subject | biosynthesis | - |
dc.subject | antifungal activity | - |
dc.subject | neurotrophic activity | - |
dc.title | Development of Non-Immunosuppressive FK506 Derivatives as Antifungal and Neurotrophic Agents | - |
dc.type | Review | - |
dc.relation.issue | 1 | - |
dc.relation.volume | 30 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.index | KCI | - |
dc.relation.startpage | 1 | - |
dc.relation.lastpage | 10 | - |
dc.relation.journaltitle | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | - |
dc.identifier.doi | 10.4014/jmb.1911.11008 | - |
dc.identifier.wosid | WOS:000509743200001 | - |
dc.identifier.scopusid | 2-s2.0-85078564401 | - |
dc.author.google | Jung, Jin A. | - |
dc.author.google | Yoon, Yeo Joon | - |
dc.contributor.scopusid | 윤여준(7402126465) | - |
dc.date.modifydate | 20210708161345 | - |