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A Cytoprotective and Degradable Metal-Polyphenol Nanoshell for Single-Cell Encapsulation

Title
A Cytoprotective and Degradable Metal-Polyphenol Nanoshell for Single-Cell Encapsulation
Authors
Park, Ji HunKim, KyunghwanLee, JunoChoi, Ji YuHong, DaewhaYang, Sung HoCaruso, FrankLee, YounghoonChoi, Insung S.
Ewha Authors
박지훈
Issue Date
2014
Journal Title
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN
1433-7851JCR Link

1521-3773JCR Link
Citation
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION vol. 53, no. 46, pp. 12420 - +
Keywords
artificial sporescytoprotectionencapsulationorganic-inorganic hybrid compositestannic acid
Publisher
WILEY-V C H VERLAG GMBH
Indexed
SCI; SCIE; SCOPUS WOS
Document Type
Article
Abstract
Single-cell encapsulation promises the cytoprotection of the encased cells against lethal stressors, reminiscent of the sporulation process in nature. However, the development of a cytocompatible method for chemically mimicking the germination process (i.e., shell degradation on-demand) has been elusive, despite the shell degradation being pivotal for the practical use of functional cells as well as for single cell-based biology. We report that an artificial shell, composed of tannic acid (TA) and Fe-III, on individual Saccharomyces cerevisiae controllably degrades on-demand, while protecting the yeast from multiple external aggressors, including UV-C irradiation, lytic enzymes, and silver nanoparticles. Cell division is suppressed by the TA-Fe-III shell, but restored fully upon shell degradation. The formation of a TA-Fe-III shell would provide a versatile tool for achieving the chemical version of sporulation and germination.
DOI
10.1002/anie.201405905
Appears in Collections:
사범대학 > 과학교육과 > Journal papers
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