View : 165 Download: 0
A Cytoprotective and Degradable Metal-Polyphenol Nanoshell for Single-Cell Encapsulation
- A Cytoprotective and Degradable Metal-Polyphenol Nanoshell for Single-Cell Encapsulation
- Park, Ji Hun; Kim, Kyunghwan; Lee, Juno; Choi, Ji Yu; Hong, Daewha; Yang, Sung Ho; Caruso, Frank; Lee, Younghoon; Choi, Insung S.
- Ewha Authors
- Issue Date
- Journal Title
- ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- ANGEWANDTE CHEMIE-INTERNATIONAL EDITION vol. 53, no. 46, pp. 12420 - +
- artificial spores; cytoprotection; encapsulation; organic-inorganic hybrid composites; tannic acid
- WILEY-V C H VERLAG GMBH
- SCIE; SCOPUS
- Document Type
- Single-cell encapsulation promises the cytoprotection of the encased cells against lethal stressors, reminiscent of the sporulation process in nature. However, the development of a cytocompatible method for chemically mimicking the germination process (i.e., shell degradation on-demand) has been elusive, despite the shell degradation being pivotal for the practical use of functional cells as well as for single cell-based biology. We report that an artificial shell, composed of tannic acid (TA) and Fe-III, on individual Saccharomyces cerevisiae controllably degrades on-demand, while protecting the yeast from multiple external aggressors, including UV-C irradiation, lytic enzymes, and silver nanoparticles. Cell division is suppressed by the TA-Fe-III shell, but restored fully upon shell degradation. The formation of a TA-Fe-III shell would provide a versatile tool for achieving the chemical version of sporulation and germination.
- Appears in Collections:
- 사범대학 > 과학교육과 > Journal papers
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.