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Novel anti-melanogenic hexapeptoids, PAL-10 and PAL-12
- Title
- Novel anti-melanogenic hexapeptoids, PAL-10 and PAL-12
- Authors
- Lee, Miri; Park, Hyeonji; Jeon, Sea Wha; Bang, JeongKyu; Chung, Ka Young; Choi, Dal Woong; Kim, EunJoo; Lim, Kyung-Min
- Ewha Authors
- 임경민
- SCOPUS Author ID
- 임경민
- Issue Date
- 2015
- Journal Title
- ARCHIVES OF DERMATOLOGICAL RESEARCH
- ISSN
- 0340-3696
1432-069X
- Citation
- ARCHIVES OF DERMATOLOGICAL RESEARCH vol. 307, no. 3, pp. 249 - 257
- Keywords
- Peptoid; Melanogenesis; Zebrafish; 3D human skin models; Tyrosinase
- Publisher
- SPRINGER
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Diverse compound sources are being explored for de-pigmentation activities to develop novel therapeutic agents or functional cosmetic ingredients for hyper-pigmentation disorders. Peptoids are a class of peptidomimetics whose side chains are appended to the nitrogen atom of the peptide backbone, instead of alpha-carbon. Peptoids are more durable against proteolysis and are being actively investigated in drug discovery, but rarely studied as cosmetic ingredients. Here, we demonstrated that new hexa-peptoids, PAL-10 and PAL-12, can inhibit melanogenesis in B16F10 melanoma cells, a 3D pigmented human skin model (Neoderm(A (R))-ME, Tegoscience Co) and zebrafish. Anti-melanogenic effects of PAL-10 or PAL-12 as compared with arbutin, a positive control in B16F10 cells, Neoderm(A (R))-ME and zebrafish were statistically significant and concentration-dependent anti-melanogenic effects were manifested as determined by image, histology, and melanin contents. Anti-melanogenic effects of PAL-10 appeared to be from enzymatic inhibition of tyrosinase while mRNA expression of melanogenic enzymes was not affected. In conclusion, we demonstrated that PAL-10 and PAL-12 can be used as a new cosmetic ingredient with strong brightening efficacies.
- DOI
- 10.1007/s00403-015-1555-1
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
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