Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 임경민 | * |
dc.date.accessioned | 2019-11-19T16:31:12Z | - |
dc.date.available | 2019-11-19T16:31:12Z | - |
dc.date.issued | 2015 | * |
dc.identifier.issn | 0340-3696 | * |
dc.identifier.issn | 1432-069X | * |
dc.identifier.other | OAK-25753 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/252114 | - |
dc.description.abstract | Diverse compound sources are being explored for de-pigmentation activities to develop novel therapeutic agents or functional cosmetic ingredients for hyper-pigmentation disorders. Peptoids are a class of peptidomimetics whose side chains are appended to the nitrogen atom of the peptide backbone, instead of alpha-carbon. Peptoids are more durable against proteolysis and are being actively investigated in drug discovery, but rarely studied as cosmetic ingredients. Here, we demonstrated that new hexa-peptoids, PAL-10 and PAL-12, can inhibit melanogenesis in B16F10 melanoma cells, a 3D pigmented human skin model (Neoderm(A (R))-ME, Tegoscience Co) and zebrafish. Anti-melanogenic effects of PAL-10 or PAL-12 as compared with arbutin, a positive control in B16F10 cells, Neoderm(A (R))-ME and zebrafish were statistically significant and concentration-dependent anti-melanogenic effects were manifested as determined by image, histology, and melanin contents. Anti-melanogenic effects of PAL-10 appeared to be from enzymatic inhibition of tyrosinase while mRNA expression of melanogenic enzymes was not affected. In conclusion, we demonstrated that PAL-10 and PAL-12 can be used as a new cosmetic ingredient with strong brightening efficacies. | * |
dc.language | English | * |
dc.publisher | SPRINGER | * |
dc.subject | Peptoid | * |
dc.subject | Melanogenesis | * |
dc.subject | Zebrafish | * |
dc.subject | 3D human skin models | * |
dc.subject | Tyrosinase | * |
dc.title | Novel anti-melanogenic hexapeptoids, PAL-10 and PAL-12 | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 307 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 249 | * |
dc.relation.lastpage | 257 | * |
dc.relation.journaltitle | ARCHIVES OF DERMATOLOGICAL RESEARCH | * |
dc.identifier.doi | 10.1007/s00403-015-1555-1 | * |
dc.identifier.wosid | WOS:000351401000006 | * |
dc.author.google | Lee, Miri | * |
dc.author.google | Park, Hyeonji | * |
dc.author.google | Jeon, Sea Wha | * |
dc.author.google | Bang, JeongKyu | * |
dc.author.google | Chung, Ka Young | * |
dc.author.google | Choi, Dal Woong | * |
dc.author.google | Kim, EunJoo | * |
dc.author.google | Lim, Kyung-Min | * |
dc.contributor.scopusid | 임경민(8916551700) | * |
dc.date.modifydate | 20240220115649 | * |