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Artificial Spores: Immunoprotective Nanocoating of Red Blood Cells with Supramolecular Ferric Ion-Tannic Acid Complex

Title
Artificial Spores: Immunoprotective Nanocoating of Red Blood Cells with Supramolecular Ferric Ion-Tannic Acid Complex
Authors
Park, TaegyunKim, Ji YupCho, HyeoncheolMoon, Hee ChulKim, Beom JinPark, Ji HunHong, DaewhaPark, JoonhongChoi, Insung S.
Ewha Authors
박지훈
Issue Date
2017
Journal Title
POLYMERS
ISSN
2073-4360JCR Link
Citation
POLYMERS vol. 9, no. 4
Keywords
artificial sporescell-surface engineeringimmunoprotectionnanocoatingred blood cellssupramolecular complex
Publisher
MDPI AG
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
The blood-type-mismatch problem, in addition to shortage of blood donation, in blood transfusion has prompted the researchers to develop universal blood that does not require blood typing. In this work, the "cell-in-shell" (i.e., artificial spore) approach is utilized to shield the immune-provoking epitopes on the surface of red blood cells (RBCs). Individual RBCs are successfully coated with supramolecular metal-organic coordination complex of ferric ion (Fe-III) and tannic acid (TA). The use of isotonic saline (0.85% NaCl) is found to be critical in the formation of stable, reasonably thick (20 nm) shells on RBCs without any aggregation and hemolysis. The formed "RBC-in-shell" structures maintain their original shapes, and effectively attenuate the antibody-mediated agglutination. Moreover, the oxygen-carrying capability of RBCs is not deteriorated after shell formation. This work suggests a simple but fast method for generating immune-camouflaged RBCs, which would contribute to the development of universal blood.
DOI
10.3390/polym9040140
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사범대학 > 과학교육과 > Journal papers
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