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Artificial Spores: Immunoprotective Nanocoating of Red Blood Cells with Supramolecular Ferric Ion-Tannic Acid Complex
- Artificial Spores: Immunoprotective Nanocoating of Red Blood Cells with Supramolecular Ferric Ion-Tannic Acid Complex
- Park, Taegyun; Kim, Ji Yup; Cho, Hyeoncheol; Moon, Hee Chul; Kim, Beom Jin; Park, Ji Hun; Hong, Daewha; Park, Joonhong; Choi, Insung S.
- Ewha Authors
- Issue Date
- Journal Title
- POLYMERS vol. 9, no. 4
- artificial spores; cell-surface engineering; immunoprotection; nanocoating; red blood cells; supramolecular complex
- MDPI AG
- SCIE; SCOPUS
- Document Type
- The blood-type-mismatch problem, in addition to shortage of blood donation, in blood transfusion has prompted the researchers to develop universal blood that does not require blood typing. In this work, the "cell-in-shell" (i.e., artificial spore) approach is utilized to shield the immune-provoking epitopes on the surface of red blood cells (RBCs). Individual RBCs are successfully coated with supramolecular metal-organic coordination complex of ferric ion (Fe-III) and tannic acid (TA). The use of isotonic saline (0.85% NaCl) is found to be critical in the formation of stable, reasonably thick (20 nm) shells on RBCs without any aggregation and hemolysis. The formed "RBC-in-shell" structures maintain their original shapes, and effectively attenuate the antibody-mediated agglutination. Moreover, the oxygen-carrying capability of RBCs is not deteriorated after shell formation. This work suggests a simple but fast method for generating immune-camouflaged RBCs, which would contribute to the development of universal blood.
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