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The effect of antioxidant and whitening action on Plantago asiatica L. leaf ethanol extract for health care

Title
The effect of antioxidant and whitening action on Plantago asiatica L. leaf ethanol extract for health care
Authors
Yoon, Mi-YunKim, Hee-JungLee, Seung-Jin
Ewha Authors
이승진김희정
SCOPUS Author ID
이승진scopus; 김희정scopusscopusscopus
Issue Date
2019
Journal Title
TECHNOLOGY AND HEALTH CARE
ISSN
0928-7329JCR Link

1878-7401JCR Link
Citation
TECHNOLOGY AND HEALTH CARE vol. 27, no. 5, pp. 567 - 577
Keywords
Plantago asiatica Lanti-oxidative activitycosmeceuticalhealthcare
Publisher
IOS PRESS
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
BACKGROUND: The Plantago asiatica L. is easy to cultivate and has been used as a folk remedy since ancient times because of various pharmacological actions such as anti-inflammation and antioxidation. It also contains a variety of flavonoids such as aucubin, which is thought to be excellent for whitening, antioxidant and anti-inflammatory action. OBJECTIVE: We investigated the effect of P. asiatica L. leaf ethanol extracts containing various active ingredients on antioxidative, anti-inflammation and whitening action and investigated its potential as a health care material. P. asiatica L. has been widely used in folk remedies. RESULTS: The cell toxicity test using RAW264.7 cells showed a high cell survival rate of over 75%, thus demonstrating the safety of the sample. In order to study the antioxidant activity of P. asiatica L. leaf ethanol extracts, we studied a sample which showed radical scavenging activity in a dose-dependent manner. To observe the antioxidant activity at the cell level, RAW 264.7 cells were used and inhibition of ROS production was measured. The ROS production was suppressed in a dose-dependent manner and the scavenging activity was stronger than the sample's own radical scavenging ability. To observe the anti-inflammatory effect of P. asiatica L. leaf ethanol extracts, inhibition of NO generation was observed using LPS-induced RAW 264.7 cells. NO generation was inhibited in a dose-dependent manner and was strongly inhibited by 31% at 100 mu g/mL. In vitro, L-DOPA and L-tyrosine were used to inhibit tyrosinase action in a dose-dependent manner. The concentration of melanin at 1, 10, and 100 mu g/mL was suppressed in B16 F10 melanin cells supplemented with alpha-MSH in the cells, and the inhibition was suppressed to 29% at 100 mu g/mL. In the B16 F10 melanin cell stimulated with MSH, the P. asiatica L. leaf ethanol extracts inhibited melanin formation in a dose-dependent manner. CONCLUSION: P. asiatica L. leaf ethanol extracts are expected to be developed as whitening cosmeceutical ingredients and as health care ingredients with antioxidant and anti-inflammatory properties.
DOI
10.3233/THC-191744
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약학대학 > 약학과 > Journal papers
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