Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이승진 | - |
dc.contributor.author | 김희정 | - |
dc.date.accessioned | 2019-11-05T16:30:14Z | - |
dc.date.available | 2019-11-05T16:30:14Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0928-7329 | - |
dc.identifier.issn | 1878-7401 | - |
dc.identifier.other | OAK-25572 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/251773 | - |
dc.description.abstract | BACKGROUND: The Plantago asiatica L. is easy to cultivate and has been used as a folk remedy since ancient times because of various pharmacological actions such as anti-inflammation and antioxidation. It also contains a variety of flavonoids such as aucubin, which is thought to be excellent for whitening, antioxidant and anti-inflammatory action. OBJECTIVE: We investigated the effect of P. asiatica L. leaf ethanol extracts containing various active ingredients on antioxidative, anti-inflammation and whitening action and investigated its potential as a health care material. P. asiatica L. has been widely used in folk remedies. RESULTS: The cell toxicity test using RAW264.7 cells showed a high cell survival rate of over 75%, thus demonstrating the safety of the sample. In order to study the antioxidant activity of P. asiatica L. leaf ethanol extracts, we studied a sample which showed radical scavenging activity in a dose-dependent manner. To observe the antioxidant activity at the cell level, RAW 264.7 cells were used and inhibition of ROS production was measured. The ROS production was suppressed in a dose-dependent manner and the scavenging activity was stronger than the sample's own radical scavenging ability. To observe the anti-inflammatory effect of P. asiatica L. leaf ethanol extracts, inhibition of NO generation was observed using LPS-induced RAW 264.7 cells. NO generation was inhibited in a dose-dependent manner and was strongly inhibited by 31% at 100 mu g/mL. In vitro, L-DOPA and L-tyrosine were used to inhibit tyrosinase action in a dose-dependent manner. The concentration of melanin at 1, 10, and 100 mu g/mL was suppressed in B16 F10 melanin cells supplemented with alpha-MSH in the cells, and the inhibition was suppressed to 29% at 100 mu g/mL. In the B16 F10 melanin cell stimulated with MSH, the P. asiatica L. leaf ethanol extracts inhibited melanin formation in a dose-dependent manner. CONCLUSION: P. asiatica L. leaf ethanol extracts are expected to be developed as whitening cosmeceutical ingredients and as health care ingredients with antioxidant and anti-inflammatory properties. | - |
dc.language | English | - |
dc.publisher | IOS PRESS | - |
dc.subject | Plantago asiatica L | - |
dc.subject | anti-oxidative activity | - |
dc.subject | cosmeceutical | - |
dc.subject | healthcare | - |
dc.title | The effect of antioxidant and whitening action on Plantago asiatica L. leaf ethanol extract for health care | - |
dc.type | Article | - |
dc.relation.issue | 5 | - |
dc.relation.volume | 27 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 567 | - |
dc.relation.lastpage | 577 | - |
dc.relation.journaltitle | TECHNOLOGY AND HEALTH CARE | - |
dc.identifier.doi | 10.3233/THC-191744 | - |
dc.identifier.wosid | WOS:000486380400011 | - |
dc.author.google | Yoon, Mi-Yun | - |
dc.author.google | Kim, Hee-Jung | - |
dc.author.google | Lee, Seung-Jin | - |
dc.contributor.scopusid | 이승진(57196249292) | - |
dc.contributor.scopusid | 김희정(57206210649) | - |
dc.date.modifydate | 20230201093329 | - |