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Up-regulation of syndecan-2 in proximal colon correlates with acute inflammation

Title
Up-regulation of syndecan-2 in proximal colon correlates with acute inflammation
Authors
Hong, HeejeongSong, Hyun-KukHwang, Eun SookLee, A. ReumHan, Dong SooKim, Seong-EunOh, Eok-Soo
Ewha Authors
오억수황은숙김성은
SCOPUS Author ID
오억수scopus; 황은숙scopus; 김성은scopus
Issue Date
2019
Journal Title
FASEB JOURNAL
ISSN
0892-6638JCR Link

1530-6860JCR Link
Citation
FASEB JOURNAL vol. 33, no. 10, pp. 11381 - 11395
Keywords
colitisIL17RAproteoglycan
Publisher
FEDERATION AMER SOC EXP BIOL
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
We previously reported that syndecan-2 expression is increased on the colonic epithelium during chronic inflammation. Here, we report that syndecan-2 exhibits a different pattern of site-specific colonic expression during acute inflammation. Syndecan-2 expression was up-regulated predominantly in the proximal colon of dextran sulfate sodium-induced colitis mice. The colitis-associated up-regulation of syndecan-2 was barely detected in Rag-1(-/-) (recombination activating gene 1 knockout) mice under colitis-inducing conditions. Increased syndecan-2 expression correlated with increased levels of infiltrated CD4(+) IL-17A(+) T cells in the proximal colon. Serum levels of IL-17A were increased during the acute inflammatory response in normal mice but not Rag-1(-/-) mice. IL-17A directly induced IL-17 receptor (IL-17RA) and syndecan-2 expression in ex vivo-cultured proximal colon tissues and adenoma cell lines from proximal colon. IL-17RA knockdown reduced the IL-17A-mediated syndecan-2 expression in SNU1235 cells. No elevation of syndecan-2 or IL-17RA was observed in colonic tissues from IL-17A(-/-) mice during colitis induction. Finally, increased expression of syndecan-2 and IL-17RA was observed in the proximal colons of cecal ligation and puncture-induced sepsis mice and infectious pan colitis patients. Together, these data suggest that acute inflammation induces syndecan-2 expression predominantly in the proximal colon via IL-17A-IL-17RA signaling during the early stage of the inflammatory response and that proximal colonic syndecan-2 might be a biomarker for acute inflammation.-Hong, H., Song, H.-K., Hwang, E. S., Lee, A. R., Han, D. S., Kim, S.-E., Oh, E.-S. Up-regulation of syndecan-2 in proximal colon correlates with acute inflammation.
DOI
10.1096/fj.201900561R
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자연과학대학 > 생명과학전공 > Journal papers
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