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Up-regulation of syndecan-2 in proximal colon correlates with acute inflammation
- Up-regulation of syndecan-2 in proximal colon correlates with acute inflammation
- Hong, Heejeong; Song, Hyun-Kuk; Hwang, Eun Sook; Lee, A. Reum; Han, Dong Soo; Kim, Seong-Eun; Oh, Eok-Soo
- Ewha Authors
- 오억수; 황은숙; 김성은
- SCOPUS Author ID
- 오억수; 황은숙; 김성은
- Issue Date
- Journal Title
- FASEB JOURNAL
- FASEB JOURNAL vol. 33, no. 10, pp. 11381 - 11395
- colitis; IL17RA; proteoglycan
- FEDERATION AMER SOC EXP BIOL
- SCIE; SCOPUS
- Document Type
- We previously reported that syndecan-2 expression is increased on the colonic epithelium during chronic inflammation. Here, we report that syndecan-2 exhibits a different pattern of site-specific colonic expression during acute inflammation. Syndecan-2 expression was up-regulated predominantly in the proximal colon of dextran sulfate sodium-induced colitis mice. The colitis-associated up-regulation of syndecan-2 was barely detected in Rag-1(-/-) (recombination activating gene 1 knockout) mice under colitis-inducing conditions. Increased syndecan-2 expression correlated with increased levels of infiltrated CD4(+) IL-17A(+) T cells in the proximal colon. Serum levels of IL-17A were increased during the acute inflammatory response in normal mice but not Rag-1(-/-) mice. IL-17A directly induced IL-17 receptor (IL-17RA) and syndecan-2 expression in ex vivo-cultured proximal colon tissues and adenoma cell lines from proximal colon. IL-17RA knockdown reduced the IL-17A-mediated syndecan-2 expression in SNU1235 cells. No elevation of syndecan-2 or IL-17RA was observed in colonic tissues from IL-17A(-/-) mice during colitis induction. Finally, increased expression of syndecan-2 and IL-17RA was observed in the proximal colons of cecal ligation and puncture-induced sepsis mice and infectious pan colitis patients. Together, these data suggest that acute inflammation induces syndecan-2 expression predominantly in the proximal colon via IL-17A-IL-17RA signaling during the early stage of the inflammatory response and that proximal colonic syndecan-2 might be a biomarker for acute inflammation.-Hong, H., Song, H.-K., Hwang, E. S., Lee, A. R., Han, D. S., Kim, S.-E., Oh, E.-S. Up-regulation of syndecan-2 in proximal colon correlates with acute inflammation.
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