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dc.contributor.author오억수-
dc.contributor.author황은숙-
dc.contributor.author김성은-
dc.date.accessioned2019-10-29T16:30:36Z-
dc.date.available2019-10-29T16:30:36Z-
dc.date.issued2019-
dc.identifier.issn0892-6638-
dc.identifier.issn1530-6860-
dc.identifier.otherOAK-25511-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/251681-
dc.description.abstractWe previously reported that syndecan-2 expression is increased on the colonic epithelium during chronic inflammation. Here, we report that syndecan-2 exhibits a different pattern of site-specific colonic expression during acute inflammation. Syndecan-2 expression was up-regulated predominantly in the proximal colon of dextran sulfate sodium-induced colitis mice. The colitis-associated up-regulation of syndecan-2 was barely detected in Rag-1(-/-) (recombination activating gene 1 knockout) mice under colitis-inducing conditions. Increased syndecan-2 expression correlated with increased levels of infiltrated CD4(+) IL-17A(+) T cells in the proximal colon. Serum levels of IL-17A were increased during the acute inflammatory response in normal mice but not Rag-1(-/-) mice. IL-17A directly induced IL-17 receptor (IL-17RA) and syndecan-2 expression in ex vivo-cultured proximal colon tissues and adenoma cell lines from proximal colon. IL-17RA knockdown reduced the IL-17A-mediated syndecan-2 expression in SNU1235 cells. No elevation of syndecan-2 or IL-17RA was observed in colonic tissues from IL-17A(-/-) mice during colitis induction. Finally, increased expression of syndecan-2 and IL-17RA was observed in the proximal colons of cecal ligation and puncture-induced sepsis mice and infectious pan colitis patients. Together, these data suggest that acute inflammation induces syndecan-2 expression predominantly in the proximal colon via IL-17A-IL-17RA signaling during the early stage of the inflammatory response and that proximal colonic syndecan-2 might be a biomarker for acute inflammation.-Hong, H., Song, H.-K., Hwang, E. S., Lee, A. R., Han, D. S., Kim, S.-E., Oh, E.-S. Up-regulation of syndecan-2 in proximal colon correlates with acute inflammation.-
dc.languageEnglish-
dc.publisherFEDERATION AMER SOC EXP BIOL-
dc.subjectcolitis-
dc.subjectIL17RA-
dc.subjectproteoglycan-
dc.titleUp-regulation of syndecan-2 in proximal colon correlates with acute inflammation-
dc.typeArticle-
dc.relation.issue10-
dc.relation.volume33-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage11381-
dc.relation.lastpage11395-
dc.relation.journaltitleFASEB JOURNAL-
dc.identifier.doi10.1096/fj.201900561R-
dc.identifier.wosidWOS:000489166300065-
dc.identifier.scopusid2-s2.0-85072717162-
dc.author.googleHong, Heejeong-
dc.author.googleSong, Hyun-Kuk-
dc.author.googleHwang, Eun Sook-
dc.author.googleLee, A. Reum-
dc.author.googleHan, Dong Soo-
dc.author.googleKim, Seong-Eun-
dc.author.googleOh, Eok-Soo-
dc.contributor.scopusid오억수(7101967153)-
dc.contributor.scopusid황은숙(8688011100)-
dc.contributor.scopusid김성은(35210756100)-
dc.date.modifydate20191105100531-
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자연과학대학 > 생명과학전공 > Journal papers
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