Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오억수 | * |
dc.contributor.author | 황은숙 | * |
dc.contributor.author | 김성은 | * |
dc.date.accessioned | 2019-10-29T16:30:36Z | - |
dc.date.available | 2019-10-29T16:30:36Z | - |
dc.date.issued | 2019 | * |
dc.identifier.issn | 0892-6638 | * |
dc.identifier.issn | 1530-6860 | * |
dc.identifier.other | OAK-25511 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/251681 | - |
dc.description.abstract | We previously reported that syndecan-2 expression is increased on the colonic epithelium during chronic inflammation. Here, we report that syndecan-2 exhibits a different pattern of site-specific colonic expression during acute inflammation. Syndecan-2 expression was up-regulated predominantly in the proximal colon of dextran sulfate sodium-induced colitis mice. The colitis-associated up-regulation of syndecan-2 was barely detected in Rag-1(-/-) (recombination activating gene 1 knockout) mice under colitis-inducing conditions. Increased syndecan-2 expression correlated with increased levels of infiltrated CD4(+) IL-17A(+) T cells in the proximal colon. Serum levels of IL-17A were increased during the acute inflammatory response in normal mice but not Rag-1(-/-) mice. IL-17A directly induced IL-17 receptor (IL-17RA) and syndecan-2 expression in ex vivo-cultured proximal colon tissues and adenoma cell lines from proximal colon. IL-17RA knockdown reduced the IL-17A-mediated syndecan-2 expression in SNU1235 cells. No elevation of syndecan-2 or IL-17RA was observed in colonic tissues from IL-17A(-/-) mice during colitis induction. Finally, increased expression of syndecan-2 and IL-17RA was observed in the proximal colons of cecal ligation and puncture-induced sepsis mice and infectious pan colitis patients. Together, these data suggest that acute inflammation induces syndecan-2 expression predominantly in the proximal colon via IL-17A-IL-17RA signaling during the early stage of the inflammatory response and that proximal colonic syndecan-2 might be a biomarker for acute inflammation.-Hong, H., Song, H.-K., Hwang, E. S., Lee, A. R., Han, D. S., Kim, S.-E., Oh, E.-S. Up-regulation of syndecan-2 in proximal colon correlates with acute inflammation. | * |
dc.language | English | * |
dc.publisher | FEDERATION AMER SOC EXP BIOL | * |
dc.subject | colitis | * |
dc.subject | IL17RA | * |
dc.subject | proteoglycan | * |
dc.title | Up-regulation of syndecan-2 in proximal colon correlates with acute inflammation | * |
dc.type | Article | * |
dc.relation.issue | 10 | * |
dc.relation.volume | 33 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 11381 | * |
dc.relation.lastpage | 11395 | * |
dc.relation.journaltitle | FASEB JOURNAL | * |
dc.identifier.doi | 10.1096/fj.201900561R | * |
dc.identifier.wosid | WOS:000489166300065 | * |
dc.identifier.scopusid | 2-s2.0-85072717162 | * |
dc.author.google | Hong, Heejeong | * |
dc.author.google | Song, Hyun-Kuk | * |
dc.author.google | Hwang, Eun Sook | * |
dc.author.google | Lee, A. Reum | * |
dc.author.google | Han, Dong Soo | * |
dc.author.google | Kim, Seong-Eun | * |
dc.author.google | Oh, Eok-Soo | * |
dc.contributor.scopusid | 오억수(7101967153) | * |
dc.contributor.scopusid | 황은숙(8688011100) | * |
dc.contributor.scopusid | 김성은(35210756100;57204243828) | * |
dc.date.modifydate | 20240422125929 | * |