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Pioneering Effects and Enhanced Neurite Complexity of Primary Hippocampal Neurons on Hierarchical Neurotemplated Scaffolds

Title
Pioneering Effects and Enhanced Neurite Complexity of Primary Hippocampal Neurons on Hierarchical Neurotemplated Scaffolds
Authors
Kim, Beom JinPark, MatthewPark, Ji HunJoo, SunghoonKim, Mi-HeeKang, KyungtaeChoi, Insung S.
Ewha Authors
박지훈
Issue Date
2018
Journal Title
ADVANCED HEALTHCARE MATERIALS
ISSN
2192-2640JCR Link

2192-2659JCR Link
Citation
ADVANCED HEALTHCARE MATERIALS vol. 7, no. 18
Keywords
axonal pathfindinghierarchical topographiesneurite complexityneurotemplated scaffoldspioneer neurons
Publisher
WILEY
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
In this work, the use of scaffolds is reported, templated from live neurons as an advanced culture platform for primary neurons. Hippocampal neurons cultured on neurotemplated scaffolds exhibit an affinity for templated somas, revealing a preference for micrometric structures amidst nanotopographical features. It is also reported, for the first time, that neurite complexity can be topographically controlled by increasing the density of nanometric features on neurotemplated scaffolds. Neurotemplated scaffolds are versatile, hierarchical topographies that feature biologically relevant structures, in both form and scale, and capture the true complexity of an in vivo environment. The introduction and implementation of neurotemplated scaffolds is sure to advance research in the fields of neurodevelopment, network development, and neuroregeneration.
DOI
10.1002/adhm.201800289
Appears in Collections:
사범대학 > 과학교육과 > Journal papers
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