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dc.contributor.author김유리-
dc.date.accessioned2019-06-26T16:30:03Z-
dc.date.available2019-06-26T16:30:03Z-
dc.date.issued2019-
dc.identifier.issn1436-6207-
dc.identifier.issn1436-6215-
dc.identifier.otherOAK-24959-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/249992-
dc.description.abstractPurposeWalnuts (Juglans regia) are known to have anti-cancer and immunomodulatory effects. However, little information is available on the effects of walnut phenolic extract (WPE) on intestinal inflammation and colitis-associated colon cancer.MethodsCOLO205 cells were pretreated with WPE and then stimulated with tumor necrosis factor (TNF)-. In the acute colitis model, wild type mice (C57BL/6) were administered 4% dextran sulfate sodium (DSS) for 5 days. In the chronic colitis model, interleukin (IL)-10(-/-) mice were administered with either the vehicle or WPE (20mg/kg) by oral gavage daily for 2 weeks. In an inflammation-associated tumor model, wild type mice were administered a single intraperitoneal injection of azoxymethane followed by three cycles of 2% DSS for 5 days and 2 weeks of free water consumption.ResultsWPE significantly inhibited IL-8 and IL-1 expression in COLO205 cells. WPE attenuated both the TNF--induced IB phosphorylation/degradation and NF-B DNA binding activity. The administration of oral WPE significantly reduced the severity of colitis in both acute and chronic colitis models, including the IL-10(-/-) mice. In immunohistochemical staining, WPE attenuated NF-B signaling in the colons of both colitis models. Finally, WPE also significantly reduced tumor development in a murine model of colitis-associated colon cancer (CAC).ConclusionsWPE ameliorates acute and chronic colitis and CAC in mice, suggesting that WPE may have potentials for the treatment of inflammatory bowel disease.-
dc.languageEnglish-
dc.publisherSPRINGER HEIDELBERG-
dc.subjectWalnut-
dc.subjectInflammatory bowel disease-
dc.subjectNuclear factor kappaB-
dc.subjectColon cancer-
dc.titleWalnut phenolic extract inhibits nuclear factor kappaB signaling in intestinal epithelial cells, and ameliorates experimental colitis and colitis-associated colon cancer in mice-
dc.typeArticle-
dc.relation.issue4-
dc.relation.volume58-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage1603-
dc.relation.lastpage1613-
dc.relation.journaltitleEUROPEAN JOURNAL OF NUTRITION-
dc.identifier.doi10.1007/s00394-018-1704-3-
dc.identifier.wosidWOS:000471256100022-
dc.author.googleKoh, Seong-Joon-
dc.author.googleChoi, Youn-I-
dc.author.googleKim, Yuri-
dc.author.googleKim, Yoo-Sun-
dc.author.googleChoi, Sang Woon-
dc.author.googleKim, Ji Won-
dc.author.googleKim, Byeong Gwan-
dc.author.googleLee, Kook Lae-
dc.contributor.scopusid김유리(37066214900)-
dc.date.modifydate20200301081000-
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신산업융합대학 > 식품영양학과 > Journal papers
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