Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 김유리 | * |
dc.date.accessioned | 2019-06-26T16:30:03Z | - |
dc.date.available | 2019-06-26T16:30:03Z | - |
dc.date.issued | 2019 | * |
dc.identifier.issn | 1436-6207 | * |
dc.identifier.issn | 1436-6215 | * |
dc.identifier.other | OAK-24959 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/249992 | - |
dc.description.abstract | PurposeWalnuts (Juglans regia) are known to have anti-cancer and immunomodulatory effects. However, little information is available on the effects of walnut phenolic extract (WPE) on intestinal inflammation and colitis-associated colon cancer.MethodsCOLO205 cells were pretreated with WPE and then stimulated with tumor necrosis factor (TNF)-. In the acute colitis model, wild type mice (C57BL/6) were administered 4% dextran sulfate sodium (DSS) for 5 days. In the chronic colitis model, interleukin (IL)-10(-/-) mice were administered with either the vehicle or WPE (20mg/kg) by oral gavage daily for 2 weeks. In an inflammation-associated tumor model, wild type mice were administered a single intraperitoneal injection of azoxymethane followed by three cycles of 2% DSS for 5 days and 2 weeks of free water consumption.ResultsWPE significantly inhibited IL-8 and IL-1 expression in COLO205 cells. WPE attenuated both the TNF--induced IB phosphorylation/degradation and NF-B DNA binding activity. The administration of oral WPE significantly reduced the severity of colitis in both acute and chronic colitis models, including the IL-10(-/-) mice. In immunohistochemical staining, WPE attenuated NF-B signaling in the colons of both colitis models. Finally, WPE also significantly reduced tumor development in a murine model of colitis-associated colon cancer (CAC).ConclusionsWPE ameliorates acute and chronic colitis and CAC in mice, suggesting that WPE may have potentials for the treatment of inflammatory bowel disease. | * |
dc.language | English | * |
dc.publisher | SPRINGER HEIDELBERG | * |
dc.subject | Walnut | * |
dc.subject | Inflammatory bowel disease | * |
dc.subject | Nuclear factor kappaB | * |
dc.subject | Colon cancer | * |
dc.title | Walnut phenolic extract inhibits nuclear factor kappaB signaling in intestinal epithelial cells, and ameliorates experimental colitis and colitis-associated colon cancer in mice | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 58 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1603 | * |
dc.relation.lastpage | 1613 | * |
dc.relation.journaltitle | EUROPEAN JOURNAL OF NUTRITION | * |
dc.identifier.doi | 10.1007/s00394-018-1704-3 | * |
dc.identifier.wosid | WOS:000471256100022 | * |
dc.author.google | Koh, Seong-Joon | * |
dc.author.google | Choi, Youn-I | * |
dc.author.google | Kim, Yuri | * |
dc.author.google | Kim, Yoo-Sun | * |
dc.author.google | Choi, Sang Woon | * |
dc.author.google | Kim, Ji Won | * |
dc.author.google | Kim, Byeong Gwan | * |
dc.author.google | Lee, Kook Lae | * |
dc.contributor.scopusid | 김유리(37066214900;55581176400) | * |
dc.date.modifydate | 20240130115050 | * |