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L-histidine and L-carnosine accelerate wound healing via regulation of corticosterone and PI3K/Akt phosphorylation in D-galactose-induced aging models in vitro and in vivo

Title
L-histidine and L-carnosine accelerate wound healing via regulation of corticosterone and PI3K/Akt phosphorylation in D-galactose-induced aging models in vitro and in vivo
Authors
Kim Y.Kim E.
Ewha Authors
김유리
SCOPUS Author ID
김유리scopus
Issue Date
2019
Journal Title
Journal of Functional Foods
ISSN
1756-4646JCR Link
Citation
Journal of Functional Foods vol. 58, pp. 227 - 237
Keywords
CorticosteroneD-galactoseL-carnosineL-histidineSkin agingWound healing
Publisher
Elsevier Ltd
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Impaired skin wound healing in the elderly can lead to medical issues and increased mortality. Although L-histidine and L-carnosine are potent anti-aging amino acids, the wound healing effects of these amino acids in aging remain to be elucidated. Here, we investigated the regenerative potential of L-histidine and L-carnosine in in vitro and in vivo aging models. L-histidine (1 mM), L-carnosine (10 mM), or a combination improved proliferation, migration, senescence, and epithelial-mesenchymal transition (EMT)in D-galactose-induced aged keratinocytes. An in vivo mouse aging model was established with injection of D-galactose (s.c. 500 mg/kg)daily for eight weeks. Supplementation with L-histidine (2 g/L), L-carnosine (2 g/L), or a combination improved collagen and wound healing with EMT markers, E-cadherin, N-cadherin, and MMP-2. These effects were concomitant with reduced circulating levels of corticosterone and increased PI3K/Akt phosphorylation. These results suggest that L-histidine and L-carnosine have the potential to facilitate wound healing in aging skin. © 2019 Elsevier Ltd
DOI
10.1016/j.jff.2019.04.060
Appears in Collections:
신산업융합대학 > 식품영양학과 > Journal papers
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