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Natural Products and Obesity: A Focus on the Regulation of Mitotic Clonal Expansion during Adipogenesis
- Title
- Natural Products and Obesity: A Focus on the Regulation of Mitotic Clonal Expansion during Adipogenesis
- Authors
- Chang, Eugene; Kim, Choon Young
- Ewha Authors
- 장유진
- SCOPUS Author ID
- 장유진
- Issue Date
- 2019
- Journal Title
- MOLECULES
- ISSN
- 1420-3049
- Citation
- MOLECULES vol. 24, no. 6
- Keywords
- obesity; adipocyte differentiation; adipogenesis; natural products; 3T3-L1 preadipocytes
- Publisher
- MDPI
- Indexed
- SCIE; SCOPUS
- Document Type
- Review
- Abstract
- Obesity is recognized as a worldwide health crisis. Obesity and its associated health complications such as diabetes, dyslipidemia, hypertension, and cardiovascular diseases impose a big social and economic burden. In an effort to identify safe, efficient, and long-term effective methods to treat obesity, various natural products with potential for inhibiting adipogenesis were revealed. This review aimed to discuss the molecular mechanisms underlying adipogenesis and the inhibitory effects of various phytochemicals, including those from natural sources, on the early stage of adipogenesis. We discuss key steps (proliferation and cell cycle) and their regulators (cell-cycle regulator, transcription factors, and intracellular signaling pathways) at the early stage of adipocyte differentiation as the mechanisms responsible for obesity.
- DOI
- 10.3390/molecules24061157
- Appears in Collections:
- 신산업융합대학 > 식품영양학과 > Journal papers
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