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Cerebral blood volume mapping using Fourier-transform-based velocity-selective saturation pulse trains
- Title
- Cerebral blood volume mapping using Fourier-transform-based velocity-selective saturation pulse trains
- Authors
- Qin, Qin; Qu, Yaoming; Li, Wenbo; Liu, Dapeng; Shin, Taehoon; Zhao, Yansong; Lin, Doris D.; van Zijl, Peter C. M.; Wen, Zhibo
- Ewha Authors
- 신태훈
- SCOPUS Author ID
- 신태훈
- Issue Date
- 2019
- Journal Title
- MAGNETIC RESONANCE IN MEDICINE
- ISSN
- 0740-3194
1522-2594
- Citation
- MAGNETIC RESONANCE IN MEDICINE vol. 81, no. 6, pp. 3544 - 3554
- Keywords
- arterial spin labeling; cerebral blood volume; eddy current; Fourier-transform-based velocity-selective saturation; velocity-selective pulse train
- Publisher
- WILEY
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Purpose: Velocity-selective saturation (VSS) pulse trains provide a viable alternative to the spatially selective methods for measuring cerebral blood volume (CBV) by reducing the sensitivity to arterial transit time. This study is to compare the Fourier-transformbased velocity-selective saturation (FT-VSS) pulse trains with the conventional flow-dephasing VSS techniques for CBV quantification. Methods: The proposed FT-VSS label and control modules were compared with VSS pulse trains utilizing double refocused hyperbolic tangent (DRHT) and 8-segment B1-insensitive rotation (BIR-8). This was done using both numerical simulations and phantom studies to evaluate their sensitivities to gradient imperfections such as eddy currents. DRHT, BIR-8, and FT-VSS prepared CBV mapping was further compared for velocity-encoding gradients along 3 orthogonal directions in healthy subjects at 3T. Results: The phantom studies exhibited more consistent immunity to gradient imperfections for the utilized FT-VSS pulse trains. Compared to DRHT and BIR-8, FT-VSS delivered more robust CBV results across the 3 VS encoding directions with significantly reduced artifacts along the superior-inferior direction and improved temporal signal-to-noise ratio (SNR) values. Average CBV values obtained from FT-VSS based sequences were 5.3 mL/100 g for gray matter and 2.3 mL/100 g for white matter, comparable to literature expectations. Conclusion: Absolute CBV quantification utilizing advanced FT-VSS pulse trains had several advantages over the existing approaches using flow-dephasing VSS modules. A greater immunity to gradient imperfections and the concurrent tissue background suppression of FT-VSS pulse trains enabled more robust CBV measurements and higher SNR than the conventional VSS pulse trains.
- DOI
- 10.1002/mrm.27668
- Appears in Collections:
- 공과대학 > 휴먼기계바이오공학과 > Journal papers
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