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Anti-Inflammatory Effects of Catalpalactone Isolated from Catalpa ovata in LPS-Induced RAW264.7 Cells
- Title
- Anti-Inflammatory Effects of Catalpalactone Isolated from Catalpa ovata in LPS-Induced RAW264.7 Cells
- Authors
- Kim, Hyo-Young; Han, Ah-Reum; Kil, Yun-Seo; Seo, Eun Kyoung; Jin, Chang Hyun
- Ewha Authors
- 서은경
- SCOPUS Author ID
- 서은경
- Issue Date
- 2019
- Journal Title
- MOLECULES
- ISSN
- 1420-3049
- Citation
- MOLECULES vol. 24, no. 7
- Keywords
- Catalpa ovata; catalpalactone; lipopolysaccharide; NF-kappa B; IRF3
- Publisher
- MDPI
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Catalpa ovata (Bignoniaceae) is widely distributed throughout Korea, China, and Japan. This study investigated the anti-inflammatory effects of catalpalactone isolated from C. ovata in lipopolysaccharide (LPS)-induced RAW264.7 cells. Catalpalactone significantly inhibited nitric oxide (NO) production and inducible NO synthase (iNOS) expression in LPS-induced RAW264.7 cells. The levels of cytokines such as interleukin-6 and tumor necrosis factor-alpha were reduced under catalpalactone exposure in LPS-induced RAW264.7 cells. Additionally, catalpalactone suppressed signal transducer and activator of transcription 1 (STAT-1) protein expression and interferon-beta (IFN-beta) production. Treatment with catalpalactone prevented interferon regulatory factor 3 (IRF3) and nuclear factor-kappa B (NF-kappa B) activation. Taken together, these results suggest that the anti-inflammatory effects of catalpalactone are associated with the suppression of NO production and iNOS expression through the inhibition of IRF3, NF-kappa B, and IFN-beta/STAT-1 activation.
- DOI
- 10.3390/molecules24071236
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
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