Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 서은경 | * |
dc.date.accessioned | 2019-05-03T16:30:08Z | - |
dc.date.available | 2019-05-03T16:30:08Z | - |
dc.date.issued | 2019 | * |
dc.identifier.issn | 1420-3049 | * |
dc.identifier.other | OAK-24694 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/249724 | - |
dc.description.abstract | Catalpa ovata (Bignoniaceae) is widely distributed throughout Korea, China, and Japan. This study investigated the anti-inflammatory effects of catalpalactone isolated from C. ovata in lipopolysaccharide (LPS)-induced RAW264.7 cells. Catalpalactone significantly inhibited nitric oxide (NO) production and inducible NO synthase (iNOS) expression in LPS-induced RAW264.7 cells. The levels of cytokines such as interleukin-6 and tumor necrosis factor-alpha were reduced under catalpalactone exposure in LPS-induced RAW264.7 cells. Additionally, catalpalactone suppressed signal transducer and activator of transcription 1 (STAT-1) protein expression and interferon-beta (IFN-beta) production. Treatment with catalpalactone prevented interferon regulatory factor 3 (IRF3) and nuclear factor-kappa B (NF-kappa B) activation. Taken together, these results suggest that the anti-inflammatory effects of catalpalactone are associated with the suppression of NO production and iNOS expression through the inhibition of IRF3, NF-kappa B, and IFN-beta/STAT-1 activation. | * |
dc.language | English | * |
dc.publisher | MDPI | * |
dc.subject | Catalpa ovata | * |
dc.subject | catalpalactone | * |
dc.subject | lipopolysaccharide | * |
dc.subject | NF-kappa B | * |
dc.subject | IRF3 | * |
dc.title | Anti-Inflammatory Effects of Catalpalactone Isolated from Catalpa ovata in LPS-Induced RAW264.7 Cells | * |
dc.type | Article | * |
dc.relation.issue | 7 | * |
dc.relation.volume | 24 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | MOLECULES | * |
dc.identifier.doi | 10.3390/molecules24071236 | * |
dc.identifier.wosid | WOS:000464956200013 | * |
dc.identifier.scopusid | 2-s2.0-85063795599 | * |
dc.author.google | Kim, Hyo-Young | * |
dc.author.google | Han, Ah-Reum | * |
dc.author.google | Kil, Yun-Seo | * |
dc.author.google | Seo, Eun Kyoung | * |
dc.author.google | Jin, Chang Hyun | * |
dc.contributor.scopusid | 서은경(7005953758) | * |
dc.date.modifydate | 20240118144717 | * |