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Bombyxamycins A and B, Cytotoxic Macrocyclic Lactams from an Intestinal Bacterium of the Silkworm Bombyx mori

Title
Bombyxamycins A and B, Cytotoxic Macrocyclic Lactams from an Intestinal Bacterium of the Silkworm Bombyx mori
Authors
Shin Y.-H.Beom J.Y.Chung B.Shin Y.Byun W.S.Moon K.Bae M.Lee S.K.Oh K.-B.Shin J.Yoon Y.J.Oh D.-C.
Ewha Authors
윤여준
SCOPUS Author ID
윤여준scopus
Issue Date
2019
Journal Title
Organic Letters
ISSN
1523-7060JCR Link
Citation
Organic Letters vol. 21, no. 6, pp. 1804 - 1808
Publisher
American Chemical Society
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Bombyxamycins A and B (1 and 2) were discovered from a silkworm gut Streptomyces bacterium. Spectroscopic analysis and multiple-step chemical derivatization identified them as 26-membered cyclic lactams with polyene features. Bombyxamycin A showed significant antibacterial and antiproliferative effects. The bombyxamycin biosynthetic gene cluster was identified by genetic analysis. Gene deletion experiments confirmed that the cytochrome P450 BomK is responsible for the generation of 2, which unprecedentedly bears tetrahydrofuran in its macrocyclic ring. © 2019 American Chemical Society.
DOI
10.1021/acs.orglett.9b00384
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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