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dc.contributor.author윤여준-
dc.date.accessioned2019-04-16T16:30:11Z-
dc.date.available2019-04-16T16:30:11Z-
dc.date.issued2019-
dc.identifier.issn1523-7060-
dc.identifier.issn1523-7052-
dc.identifier.otherOAK-24594-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/249630-
dc.description.abstractBombyxamycins A and B (1 and 2) were discovered from a silkworm gut Streptomyces bacterium. Spectroscopic analysis and multiple-step chemical derivatization identified them as 26-membered cyclic lactams with polyene features. Bombyxamycin A showed significant antibacterial and antiproliferative effects. The bombyxamycin biosynthetic gene cluster was identified by genetic analysis. Gene deletion experiments confirmed that the cytochrome P450 BomK is responsible for the generation of 2, which unprecedentedly bears tetrahydrofuran in its macrocyclic ring.-
dc.languageEnglish-
dc.publisherAMER CHEMICAL SOC-
dc.titleBombyxamycins A and B, Cytotoxic Macrocyclic Lactams from an Intestinal Bacterium of the Silkworm Bombyx mori-
dc.typeArticle-
dc.relation.issue6-
dc.relation.volume21-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage1804-
dc.relation.lastpage1808-
dc.relation.journaltitleORGANIC LETTERS-
dc.identifier.doi10.1021/acs.orglett.9b00384-
dc.identifier.wosidWOS:000461843900054-
dc.identifier.scopusid2-s2.0-85062484412-
dc.author.googleShin, Yern-Hyerk-
dc.author.googleBeom, Ji Yoon-
dc.author.googleChung, Beomkoo-
dc.author.googleShin, Yoonho-
dc.author.googleByun, Woong Sub-
dc.author.googleMoon, Kyuho-
dc.author.googleBae, Munhyung-
dc.author.googleLee, Sang Kook-
dc.author.googleOh, Ki-Bong-
dc.author.googleShin, Jongheon-
dc.author.googleYoon, Yeo Joon-
dc.author.googleOh, Dong-Chan-
dc.contributor.scopusid윤여준(7402126465)-
dc.date.modifydate20190524100615-
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자연과학대학 > 화학·나노과학전공 > Journal papers
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