View : 27 Download: 0

Saccharoquinoline, a Cytotoxic Alkaloidal Meroterpenoid from Marine-Derived Bacterium Saccharomonospora sp.

Title
Saccharoquinoline, a Cytotoxic Alkaloidal Meroterpenoid from Marine-Derived Bacterium Saccharomonospora sp.
Authors
Le, Tu CamLee, Eun JuLee, JihyeHong, AhreumYim, Chae-YoonYang, InhoChoi, HyukjaeChin, JungwookCho, Sung JinKo, JaeyoungHwang, HayoungNam, Sang-JipFenical, William
Ewha Authors
남상집
SCOPUS Author ID
남상집scopus
Issue Date
2019
Journal Title
MARINE DRUGS
ISSN
1660-3397JCR Link
Citation
MARINE DRUGS vol. 17, no. 2
Keywords
Saccharomonospora spmeroterpenoidmarine natural productcytotoxicity
Publisher
MDPI
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
A cytotoxic alkaloidal meroterpenoid, saccharoquinoline (1), has been isolated from the fermentation broth of the marine-derived bacterium Saccharomonospora sp. CNQ-490. The planar structure of 1 was elucidated by 1D, 2D NMR, and MS spectroscopic data analyzes, while the relative configuration of 1 was defined through the interpretation of NOE spectroscopic data. Saccharoquinoline (1) is composed of a drimane-type sesquiterpene unit in combination with an apparent 6,7,8-trihydroxyquinoline-2-carboxylic acid. This combination of biosynthetic pathways was observed for the first time in natural microbial products. Saccharoquinoline (1) was found to have cytotoxicity against the HCT-116 cancer cell line by inducing G1 arrest, which leads to cell growth inhibition.
DOI
10.3390/md17020098
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE