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dc.contributor.author남상집-
dc.date.accessioned2019-04-15T16:30:11Z-
dc.date.available2019-04-15T16:30:11Z-
dc.date.issued2019-
dc.identifier.issn1660-3397-
dc.identifier.otherOAK-24419-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/249571-
dc.description.abstractA cytotoxic alkaloidal meroterpenoid, saccharoquinoline (1), has been isolated from the fermentation broth of the marine-derived bacterium Saccharomonospora sp. CNQ-490. The planar structure of 1 was elucidated by 1D, 2D NMR, and MS spectroscopic data analyzes, while the relative configuration of 1 was defined through the interpretation of NOE spectroscopic data. Saccharoquinoline (1) is composed of a drimane-type sesquiterpene unit in combination with an apparent 6,7,8-trihydroxyquinoline-2-carboxylic acid. This combination of biosynthetic pathways was observed for the first time in natural microbial products. Saccharoquinoline (1) was found to have cytotoxicity against the HCT-116 cancer cell line by inducing G1 arrest, which leads to cell growth inhibition.-
dc.languageEnglish-
dc.publisherMDPI-
dc.subjectSaccharomonospora sp-
dc.subjectmeroterpenoid-
dc.subjectmarine natural product-
dc.subjectcytotoxicity-
dc.titleSaccharoquinoline, a Cytotoxic Alkaloidal Meroterpenoid from Marine-Derived Bacterium Saccharomonospora sp.-
dc.typeArticle-
dc.relation.issue2-
dc.relation.volume17-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.journaltitleMARINE DRUGS-
dc.identifier.doi10.3390/md17020098-
dc.identifier.wosidWOS:000460795500026-
dc.identifier.scopusid2-s2.0-85061145749-
dc.author.googleLe, Tu Cam-
dc.author.googleLee, Eun Ju-
dc.author.googleLee, Jihye-
dc.author.googleHong, Ahreum-
dc.author.googleYim, Chae-Yoon-
dc.author.googleYang, Inho-
dc.author.googleChoi, Hyukjae-
dc.author.googleChin, Jungwook-
dc.author.googleCho, Sung Jin-
dc.author.googleKo, Jaeyoung-
dc.author.googleHwang, Hayoung-
dc.author.googleNam, Sang-Jip-
dc.author.googleFenical, William-
dc.contributor.scopusid남상집(36455982300)-
dc.date.modifydate20190822144107-
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자연과학대학 > 화학·나노과학전공 > Journal papers
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