Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 남상집 | * |
dc.date.accessioned | 2019-04-15T16:30:11Z | - |
dc.date.available | 2019-04-15T16:30:11Z | - |
dc.date.issued | 2019 | * |
dc.identifier.issn | 1660-3397 | * |
dc.identifier.other | OAK-24419 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/249571 | - |
dc.description.abstract | A cytotoxic alkaloidal meroterpenoid, saccharoquinoline (1), has been isolated from the fermentation broth of the marine-derived bacterium Saccharomonospora sp. CNQ-490. The planar structure of 1 was elucidated by 1D, 2D NMR, and MS spectroscopic data analyzes, while the relative configuration of 1 was defined through the interpretation of NOE spectroscopic data. Saccharoquinoline (1) is composed of a drimane-type sesquiterpene unit in combination with an apparent 6,7,8-trihydroxyquinoline-2-carboxylic acid. This combination of biosynthetic pathways was observed for the first time in natural microbial products. Saccharoquinoline (1) was found to have cytotoxicity against the HCT-116 cancer cell line by inducing G1 arrest, which leads to cell growth inhibition. | * |
dc.language | English | * |
dc.publisher | MDPI | * |
dc.subject | Saccharomonospora sp | * |
dc.subject | meroterpenoid | * |
dc.subject | marine natural product | * |
dc.subject | cytotoxicity | * |
dc.title | Saccharoquinoline, a Cytotoxic Alkaloidal Meroterpenoid from Marine-Derived Bacterium Saccharomonospora sp. | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 17 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | MARINE DRUGS | * |
dc.identifier.doi | 10.3390/md17020098 | * |
dc.identifier.wosid | WOS:000460795500026 | * |
dc.identifier.scopusid | 2-s2.0-85061145749 | * |
dc.author.google | Le, Tu Cam | * |
dc.author.google | Lee, Eun Ju | * |
dc.author.google | Lee, Jihye | * |
dc.author.google | Hong, Ahreum | * |
dc.author.google | Yim, Chae-Yoon | * |
dc.author.google | Yang, Inho | * |
dc.author.google | Choi, Hyukjae | * |
dc.author.google | Chin, Jungwook | * |
dc.author.google | Cho, Sung Jin | * |
dc.author.google | Ko, Jaeyoung | * |
dc.author.google | Hwang, Hayoung | * |
dc.author.google | Nam, Sang-Jip | * |
dc.author.google | Fenical, William | * |
dc.contributor.scopusid | 남상집(57208839798) | * |
dc.date.modifydate | 20240220120010 | * |