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A near-infrared fluorescent probe for amyloid-β aggregates

Title
A near-infrared fluorescent probe for amyloid-β aggregates
Authors
Lee M.Kim M.Tikum A.F.Lee H.J.Thamilarasan V.Lim M.H.Kim J.
Ewha Authors
김진흥
SCOPUS Author ID
김진흥scopus
Issue Date
2019
Journal Title
Dyes and Pigments
ISSN
0143-7208JCR Link
Citation
Dyes and Pigments vol. 162, pp. 97 - 103
Keywords
Amyloid-βBenzo[e]indoleDimethylaminostyreneDonor-π-acceptor systemFluorescent probe
Publisher
Elsevier Ltd
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
The deposition of amyloid-β (Aβ) aggregates in the brain is a hallmark of the Alzheimer's disease (AD)-affected brain. Various aggregated Aβ species, including oligomers and fibrils, are generated upon the aggregation process, and these Aβ aggregates have distinct biological properties. To non-invasively monitor the aggregation pathways of Aβ and identify the existence of certain Aβ species in biological environments, an effective strategy to detect Aβ species is necessary. Herein, we report a turn-on near-infrared (near-IR) fluorescent probe, 1, for Aβ aggregates, which consists of a donor-π-acceptor system with an Aβ-interacting moiety. Our probe, 1, shows a noticeable increase in near-IR fluorescence at ca. 710 nm in the presence of Aβ aggregates in aqueous media. In addition, the fluorescent response of 1 was altered depending on the degree of Aβ aggregation. Moreover, 1 indicates turn-on fluorescence with Aβ aggregates in living cells and is nontoxic under the condition used for live-cell imaging. © 2018 Elsevier Ltd
DOI
10.1016/j.dyepig.2018.10.013
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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