Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김진흥 | - |
dc.date.accessioned | 2019-01-28T16:30:12Z | - |
dc.date.available | 2019-01-28T16:30:12Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0143-7208 | - |
dc.identifier.other | OAK-24217 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/248336 | - |
dc.description.abstract | The deposition of amyloid-β (Aβ) aggregates in the brain is a hallmark of the Alzheimer's disease (AD)-affected brain. Various aggregated Aβ species, including oligomers and fibrils, are generated upon the aggregation process, and these Aβ aggregates have distinct biological properties. To non-invasively monitor the aggregation pathways of Aβ and identify the existence of certain Aβ species in biological environments, an effective strategy to detect Aβ species is necessary. Herein, we report a turn-on near-infrared (near-IR) fluorescent probe, 1, for Aβ aggregates, which consists of a donor-π-acceptor system with an Aβ-interacting moiety. Our probe, 1, shows a noticeable increase in near-IR fluorescence at ca. 710 nm in the presence of Aβ aggregates in aqueous media. In addition, the fluorescent response of 1 was altered depending on the degree of Aβ aggregation. Moreover, 1 indicates turn-on fluorescence with Aβ aggregates in living cells and is nontoxic under the condition used for live-cell imaging. © 2018 Elsevier Ltd | - |
dc.language | English | - |
dc.publisher | Elsevier Ltd | - |
dc.subject | Amyloid-β | - |
dc.subject | Benzo[e]indole | - |
dc.subject | Dimethylaminostyrene | - |
dc.subject | Donor-π-acceptor system | - |
dc.subject | Fluorescent probe | - |
dc.title | A near-infrared fluorescent probe for amyloid-β aggregates | - |
dc.type | Article | - |
dc.relation.volume | 162 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 97 | - |
dc.relation.lastpage | 103 | - |
dc.relation.journaltitle | Dyes and Pigments | - |
dc.identifier.doi | 10.1016/j.dyepig.2018.10.013 | - |
dc.identifier.wosid | WOS:000456226500013 | - |
dc.identifier.scopusid | 2-s2.0-85054860215 | - |
dc.author.google | Lee M. | - |
dc.author.google | Kim M. | - |
dc.author.google | Tikum A.F. | - |
dc.author.google | Lee H.J. | - |
dc.author.google | Thamilarasan V. | - |
dc.author.google | Lim M.H. | - |
dc.author.google | Kim J. | - |
dc.contributor.scopusid | 김진흥(8580015800) | - |
dc.date.modifydate | 20230201114415 | - |