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Multivitamin and Mineral Supplementation Containing Phytonutrients Scavenges Reactive Oxygen Species in Healthy Subjects: A Randomized, Double-Blinded, Placebo-Controlled Trial

Title
Multivitamin and Mineral Supplementation Containing Phytonutrients Scavenges Reactive Oxygen Species in Healthy Subjects: A Randomized, Double-Blinded, Placebo-Controlled Trial
Authors
Kang, SeungheeLim, YeniKim, You JinJung, Eun SungSuh, Dong HoLee, Choong HwanPark, EunmiHong, JinaVelliquette, Rodney A.Kwon, OranKim, Ji Yeon
Ewha Authors
권오란김유진임예니
SCOPUS Author ID
권오란scopus
Issue Date
2019
Journal Title
NUTRIENTS
ISSN
2072-6643JCR Link
Citation
NUTRIENTS vol. 11, no. 1
Keywords
phytonutrientsROS scavengingDNA damageantioxidant capacityhuman clinical study
Publisher
MDPI
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Phytonutrients and vitamin and mineral supplementation have been reported to provide increased antioxidant capacity in humans; however, there is still controversy. In the current clinical trial, we examined the antioxidant and DNA protection capacity of a plant-based, multi-vitamin/mineral, and phytonutrient (PMP) supplementation in healthy adults who were habitually low in the consumption of fruits and vegetables. This study was an eight-week, double-blind, randomized, parallel-arm, and placebo-controlled trial. PMP supplementation for eight weeks reduced reactive oxygen species (ROS) and prevented DNA damage without altering endogenous antioxidant system. Plasma vitamins and phytonutrients were significantly correlated with ROS scavenging and DNA damage. In addition, gene expression analysis in PBMC showed subtle changes in superoxide metabolic processes. In this study, we showed that supplementation with a PMP significantly improved ROS scavenging activity and prevented DNA damage. However, additional research is still needed to further identify mechanisms of actions and the role of circulating phytonutrient metabolites.
DOI
10.3390/nu11010101
Appears in Collections:
신산업융합대학 > 식품영양학과 > Journal papers
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