View : 1155 Download: 426
Multivitamin and Mineral Supplementation Containing Phytonutrients Scavenges Reactive Oxygen Species in Healthy Subjects: A Randomized, Double-Blinded, Placebo-Controlled Trial
- Title
- Multivitamin and Mineral Supplementation Containing Phytonutrients Scavenges Reactive Oxygen Species in Healthy Subjects: A Randomized, Double-Blinded, Placebo-Controlled Trial
- Authors
- Kang, Seunghee; Lim, Yeni; Kim, You Jin; Jung, Eun Sung; Suh, Dong Ho; Lee, Choong Hwan; Park, Eunmi; Hong, Jina; Velliquette, Rodney A.; Kwon, Oran; Kim, Ji Yeon
- Ewha Authors
- 권오란; 김유진; 임예니
- SCOPUS Author ID
- 권오란; 김유진; 임예니
- Issue Date
- 2019
- Journal Title
- NUTRIENTS
- ISSN
- 2072-6643
- Citation
- NUTRIENTS vol. 11, no. 1
- Keywords
- phytonutrients; ROS scavenging; DNA damage; antioxidant capacity; human clinical study
- Publisher
- MDPI
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Phytonutrients and vitamin and mineral supplementation have been reported to provide increased antioxidant capacity in humans; however, there is still controversy. In the current clinical trial, we examined the antioxidant and DNA protection capacity of a plant-based, multi-vitamin/mineral, and phytonutrient (PMP) supplementation in healthy adults who were habitually low in the consumption of fruits and vegetables. This study was an eight-week, double-blind, randomized, parallel-arm, and placebo-controlled trial. PMP supplementation for eight weeks reduced reactive oxygen species (ROS) and prevented DNA damage without altering endogenous antioxidant system. Plasma vitamins and phytonutrients were significantly correlated with ROS scavenging and DNA damage. In addition, gene expression analysis in PBMC showed subtle changes in superoxide metabolic processes. In this study, we showed that supplementation with a PMP significantly improved ROS scavenging activity and prevented DNA damage. However, additional research is still needed to further identify mechanisms of actions and the role of circulating phytonutrient metabolites.
- DOI
- 10.3390/nu11010101
- Appears in Collections:
- 신산업융합대학 > 식품영양학과 > Journal papers
- Files in This Item:
-
Multivitamin and Mineral Supplementation.pdf(3.48 MB)
Download
- Export
- RIS (EndNote)
- XLS (Excel)
- XML