Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 김유리 | * |
dc.date.accessioned | 2018-12-14T16:31:20Z | - |
dc.date.available | 2018-12-14T16:31:20Z | - |
dc.date.issued | 2018 | * |
dc.identifier.issn | 1976-1457 | * |
dc.identifier.other | OAK-22376 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/247893 | - |
dc.description.abstract | BACKGROUD/OBJECTIVES: The objective of this study was to investigate the effects of vitamin C on inflammation, tumor development, and dysbiosis of intestinal microbiota in an azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced inflammation-associated early colon cancer mouse model. MATERIALS/METHODS: Male BALB/c mice were injected intraperitoneally with AOM [10 mg/kg body weight (b.w)] and given two 7-d cycles of 2% DSS drinking water with a 14 d inter-cycle interval. Vitamin C (60 mg/kg b.w. and 120 mg/kg b.w.) was supplemented by gavage for 5 weeks starting 2 d after the AOM injection. RESULTS: The vitamin C treatment suppressed inflammatory morbidity, as reflected by disease activity index (DAI) in recovery phase and inhibited shortening of the colon, and reduced histological damage. In addition, vitamin C supplementation suppressed mRNA levels of pro-inflammatory mediators and cytokines, including cyclooxygenase-2, microsomal prostaglandin E synthase-2, tumor necrosis factor-α, Interleukin (IL)-1β, and IL-6, and reduced expression of the proliferation marker, proliferating cell nuclear antigen, compared to observations of AOM/DSS animals. Although the microbial composition did not differ significantly between the groups, administration of vitamin C improved the level of inflammation-related Lactococcus and JQ084893 to control levels. CONCLUSION: Vitamin C treatment provided moderate suppression of inflammation, proliferation, and certain inflammation-related dysbiosis in a murine model of colitis associated-early colon cancer. These findings support that vitamin C supplementation can benefit colonic health. Long-term clinical studies with various doses of vitamin C are warranted. © 2018 The Korean Nutrition Society and the Korean Society of Community Nutrition. | * |
dc.language | English | * |
dc.publisher | Korean Nutrition Society | * |
dc.subject | Colitis | * |
dc.subject | Colonic neoplasm | * |
dc.subject | Inflammation | * |
dc.subject | Microbiota | * |
dc.subject | Vitamin C | * |
dc.title | Effect of vitamin C on azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced colitis-associated early colon cancer in mice | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 12 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 101 | * |
dc.relation.lastpage | 109 | * |
dc.relation.journaltitle | Nutrition Research and Practice | * |
dc.identifier.doi | 10.4162/nrp.2018.12.2.101 | * |
dc.identifier.wosid | WOS:000430156500002 | * |
dc.identifier.scopusid | 2-s2.0-85045085206 | * |
dc.author.google | Jeon H.-J. | * |
dc.author.google | Yeom Y. | * |
dc.author.google | Kim Y.-S. | * |
dc.author.google | Kim E. | * |
dc.author.google | Shin J.-H. | * |
dc.author.google | Seok P.R. | * |
dc.author.google | Woo M.J. | * |
dc.author.google | Kim Y. | * |
dc.contributor.scopusid | 김유리(37066214900;55581176400) | * |
dc.date.modifydate | 20240130115050 | * |