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자연과학대학
화학·나노과학전공
Journal papers
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Fast Degradable Polycaprolactone for Drug Delivery
Title
Fast Degradable Polycaprolactone for Drug Delivery
Authors
Chang S.H.
;
Lee H.J.
;
Park S.
;
Kim Y.
;
Jeong B.
Ewha Authors
정병문
SCOPUS Author ID
정병문
Issue Date
2018
Journal Title
Biomacromolecules
ISSN
1525-7797
Citation
Biomacromolecules vol. 19, no. 6, pp. 2302 - 2307
Publisher
American Chemical Society
Indexed
SCIE; SCOPUS
Document Type
Article
Abstract
Polycaprolactone (PCL) was reported a long time ago; however, its biomedical applications has not been extensively investigated in comparison with poly(lactide-co-glycolide) (PLGA) due to its too slow degradation profile. Here, we are reporting an oxalate-connected oligocaprolactone multiblock copolymer (PCL-OX) as a fast degradable PCL while maintaining its crystalline properties and low melting point of PCL. The in vivo application of the paclitaxel-loaded PCL-OX microspheres provided a steady plasma drug concentration of 6-9 μg/mL over 28 days, similar to that of the PLGA microspheres. Both PCL and PLGA microspheres were completely cleared two months after in vivo implantation. The PCL-OX microspheres showed a similar tissue compatibility to that of PLGA microspheres in the subcutaneous layer of rats. These findings suggest that PCL-OX is a useful biomaterial that solves the slow degradation problems of PCL and, thus, may find uses in other biomedical applications as an alternative to PLGA. © 2018 American Chemical Society.
DOI
10.1021/acs.biomac.8b00266
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