Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정병문 | * |
dc.date.accessioned | 2018-12-14T16:30:55Z | - |
dc.date.available | 2018-12-14T16:30:55Z | - |
dc.date.issued | 2018 | * |
dc.identifier.issn | 1525-7797 | * |
dc.identifier.other | OAK-22596 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/247748 | - |
dc.description.abstract | Polycaprolactone (PCL) was reported a long time ago; however, its biomedical applications has not been extensively investigated in comparison with poly(lactide-co-glycolide) (PLGA) due to its too slow degradation profile. Here, we are reporting an oxalate-connected oligocaprolactone multiblock copolymer (PCL-OX) as a fast degradable PCL while maintaining its crystalline properties and low melting point of PCL. The in vivo application of the paclitaxel-loaded PCL-OX microspheres provided a steady plasma drug concentration of 6-9 μg/mL over 28 days, similar to that of the PLGA microspheres. Both PCL and PLGA microspheres were completely cleared two months after in vivo implantation. The PCL-OX microspheres showed a similar tissue compatibility to that of PLGA microspheres in the subcutaneous layer of rats. These findings suggest that PCL-OX is a useful biomaterial that solves the slow degradation problems of PCL and, thus, may find uses in other biomedical applications as an alternative to PLGA. © 2018 American Chemical Society. | * |
dc.language | English | * |
dc.publisher | American Chemical Society | * |
dc.title | Fast Degradable Polycaprolactone for Drug Delivery | * |
dc.type | Article | * |
dc.relation.issue | 6 | * |
dc.relation.volume | 19 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 2302 | * |
dc.relation.lastpage | 2307 | * |
dc.relation.journaltitle | Biomacromolecules | * |
dc.identifier.doi | 10.1021/acs.biomac.8b00266 | * |
dc.identifier.wosid | WOS:000435226200053 | * |
dc.identifier.scopusid | 2-s2.0-85046937963 | * |
dc.author.google | Chang S.H. | * |
dc.author.google | Lee H.J. | * |
dc.author.google | Park S. | * |
dc.author.google | Kim Y. | * |
dc.author.google | Jeong B. | * |
dc.contributor.scopusid | 정병문(7102237959) | * |
dc.date.modifydate | 20240118155902 | * |