Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이은경 | * |
dc.date.accessioned | 2018-12-07T16:30:36Z | - |
dc.date.available | 2018-12-07T16:30:36Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 0007-0912 | * |
dc.identifier.other | OAK-20829 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/247368 | - |
dc.description.abstract | Background: In our preliminary study, the modified Marsh (M-Marsh) model caused an inadvertent underdosing of propofol in underweight patients. However, the predictive performance of the M-Marsh and Schnider models incorporated in commercially available target-controlled infusion (TCI) pumps was not evaluated in underweight patients. Methods: Thirty underweight patients undergoing elective surgery were randomly allocated to receive propofol via TCI using the M-Marsh or Schnider models. The target effect-site concentrations (Ces) of propofol were, in order, 2.5, 3, 4, 5, 6 and 2 μg ml-1. Arterial blood samples were obtained at least 7 min after achieving each pseudo-steady-state. Results: A total of 172 plasma samples were used to determine the predictive performance of both models. The pooled median (95% confidence interval) biases and inaccuracies at a target Ce ≤ 3 μg ml-1 were-22.6 (-28.8 to-12.6) and 31.9 (24.8-36.8) for the M-Marsh model and 9.0 (1.7-16.4) and 28.5 (21.7-32.8) for the Schnider model, respectively. These values at Ce ≥ 4 μg ml-1 were-9.6 (-16.0 to-6.0) and 24.7 (21.1-27.9) for the M-Marsh model and 19.8 (12.9-25.7) and 36.2 (31.4-39.7) for the Schnider model, respectively. Conclusions: The pooled biases and inaccuracies of both models were clinically acceptable. However, the M-Marsh and Schnider models consistently produced negatively and positively biased predictions, respectively, in underweight patients. In particular, the M-Marsh model showed greater inaccuracy at target Ce ≤ 3 μg ml-1 and the Schnider model showed greater inaccuracy at target Ce ≥ 4 μg ml-1. Therefore, it is necessary to develop a new pharmacokinetic model for propofol in underweight patients. © 2017 The Author. | * |
dc.language | English | * |
dc.publisher | Oxford University Press | * |
dc.subject | model | * |
dc.subject | pharmacokinetics | * |
dc.subject | propofol | * |
dc.subject | underweight | * |
dc.title | Predictive performance of the modified Marsh and Schnider models for propofol in underweight patients undergoing general anaesthesia using target-controlled infusion | * |
dc.type | Article | * |
dc.relation.issue | 6 | * |
dc.relation.volume | 118 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 883 | * |
dc.relation.lastpage | 891 | * |
dc.relation.journaltitle | British Journal of Anaesthesia | * |
dc.identifier.doi | 10.1093/bja/aex102 | * |
dc.identifier.wosid | WOS:000402742200012 | * |
dc.identifier.scopusid | 2-s2.0-85026744394 | * |
dc.author.google | Lee Y.H. | * |
dc.author.google | Choi G.H. | * |
dc.author.google | Jung K.W. | * |
dc.author.google | Choi B.H. | * |
dc.author.google | Bang J.Y. | * |
dc.author.google | Lee E.K. | * |
dc.author.google | Choi B.M. | * |
dc.author.google | Noh G.J. | * |
dc.contributor.scopusid | 이은경(57188770360;57217075385) | * |
dc.date.modifydate | 20240123125059 | * |