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신산업융합대학
식품영양학과
Journal papers
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Analysis for doubly repeated omics data from crossover design
Title
Analysis for doubly repeated omics data from crossover design
Authors
Choi S.
;
Park S.-Y.
;
Kim H.
;
Kwon O.
;
Park T.
Ewha Authors
권오란
SCOPUS Author ID
권오란
Issue Date
2017
Journal Title
Proceedings - 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016
Citation
Proceedings - 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016, pp. 1749 - 1752
Keywords
Crossover design
;
Linear mixed effect model
;
Repeated measurements
Publisher
Institute of Electrical and Electronics Engineers Inc.
Indexed
SCOPUS
Document Type
Conference Paper
Abstract
Some crossover clinical trials produce doubly repeated omics data with two repeated factors. Linear mixed effect models (LMMs) are commonly applied to the data from the crossover design focusing on the analysis of repeatedly observed omics data themselves. Alternatively, the univariate analyses using the single summary measurements such as differences between time points and incremental area under curve (iAUC) are also widely used. In this study, we compare the performance of both methods for real doubly repeated omics data from a crossover study. © 2016 IEEE.
DOI
10.1109/BIBM.2016.7822782
ISBN
9781509016105
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