Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김양하 | * |
dc.date.accessioned | 2018-06-06T08:13:15Z | - |
dc.date.available | 2018-06-06T08:13:15Z | - |
dc.date.issued | 2003 | * |
dc.identifier.issn | 0301-4800 | * |
dc.identifier.other | OAK-17363 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/244728 | - |
dc.description.abstract | Barley, which is high in soluble dietary fiber (particularly β-glucan), is thought to have hypocholesterolemic effects. The present study was performed to further elucidate the hypocholesterolemic actions of waxy barley, and the extent to which they can be attributed to β-glucan. Male Sprague-Dawley rats (n=21) were fed control (fiber-free) diets, diets with the addition of 2.5% refined β-glucan or 30% waxy barley that provides approximately 2.5% β-glucan in the diet for 2 wk. Body weight gain and food efficiency of rats were unaffected by diet. β-glucan or waxy barley decreased serum levels of total cholesterol (p<0.05) by 13.5% or 18.9%, and also decreased LDL-cholesterol 19.4% or 24.3%, respectively. Addition of refined β-glucan or waxy barley to the diet resulted in greater bile acid excretions (p<0.05) compared to the control group. The waxy barley diet up-regulated by 2.3 times and the β-glucan diet by 1.5 times the activity of cholesterol 7 α-hydroxylase (CYP7A1). Hepatic CYP7A1 mRNA level paralleled the increases in enzyme activity. The results of this study suggest that the hypocholesterolemic effects of both β-glucan and a waxy barley diet may be due to the enhancement of CYP7A1 expression resulting from increased fecal excretion of bile acids. | * |
dc.language | English | * |
dc.title | Barley β-Glucan Lowers Serum Cholesterol Based on the Up-Regulation of Cholesterol 7 α-Hydroxylase Activity and mRNA Abundance in Cholesterol-Fed Rats | * |
dc.type | Article | * |
dc.relation.issue | 6 | * |
dc.relation.volume | 49 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 381 | * |
dc.relation.lastpage | 387 | * |
dc.relation.journaltitle | Journal of Nutritional Science and Vitaminology | * |
dc.identifier.scopusid | 2-s2.0-0347419127 | * |
dc.author.google | Yang J.-L. | * |
dc.author.google | Kim Y.-H. | * |
dc.author.google | Lee H.-S. | * |
dc.author.google | Lee M.-S. | * |
dc.author.google | Moon Y.K. | * |
dc.contributor.scopusid | 김양하(8524160300) | * |
dc.date.modifydate | 20240123090847 | * |