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Inhibition of the benzo[a]pyrene-induced toxicity by allyl sulfides in human epidermal keratinocytes

Title
Inhibition of the benzo[a]pyrene-induced toxicity by allyl sulfides in human epidermal keratinocytes
Authors
Chun H.S.Hyun J.K.Kim Y.Hyun J.C.
Ewha Authors
김양하
SCOPUS Author ID
김양하scopus
Issue Date
2004
Journal Title
Biotechnology Letters
ISSN
0141-5492JCR Link
Citation
Biotechnology Letters vol. 26, no. 22, pp. 1701 - 1706
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Diallyl sulfide (DAS) and diallyl disulfide (DADS) at 25 μg ml -1 decreased the benzo[a]pyrene (B[a]P)-induced colony growth inhibition of human epidermal keratinocytes. DAS and DADS decreased B[a]P-DNA and B[a]P-protein adducts by 65% and 49-55%, respectively. The B[a]P-induced ethoxyresorufin O-deethylase activity, a marker enzyme for cytochrome P450 1, was decreased from 3 to 1.7-1.9 nmol min -1 mg -1 microsomal protein by DAS and DADS treatments. The activity of glutathione S-transferase, a detoxifying enzyme for B[a]P, but was decreased by DADS, but was unaffected by DAS.
DOI
10.1007/s10529-004-3738-2
Appears in Collections:
신산업융합대학 > 식품영양학과 > Journal papers
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